Research Teams

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The Diane Barrière Chair « Molecular physiology of synaptic bioenergetics »
Team leader(s)
Neurophysiology Main domain: Neurophysiology Subdomain : Molecular & cellular neuroscience Jaime DE JUAN-SANZ’s team investigates mitochondrial dysfunction as a primary cause in epilepsy. Mitochondria plays a pivotal role for neuronal function, controlling three fundamental mechanisms that are essential for neuronal biology and synaptic transmission: 1) ATP production, 2) Ca2+ homeostasis and 3) apoptotic cell death. Using cutting-edge optical techniques to study bioenergetics in firing synapses in combination with precise metabolic and genetic manipulations, the team will work on developing a detailed molecular understanding of the role of synaptic mitochondrial metabolism in controlling neuronal function in health and disease. For more information
Team “Molecular Pathophysiology of Parkinson’s disease”
Team leader(s)
Jean-Christophe CORVOL MD, PhD, PU-PH, Sorbonne University, AP-HP
Physiopathology of neurogical disorders
Main domain: Cellular & molecular neuroscience
Subdomain: Clinical & translational neurosciences

Olga CORTI & Jean-Christophe CORVOL’s team proposes a multidimensional clinical, genetic/genomic and cell biology-based program aimed at deciphering and integrating the molecular heterogeneity and biological complexity of Parkinson’s Disease (PD) towards translation to clinical research. For more information
Team “Cellular mechanisms of sensory processing”
Team leader(s)
Cellular physiology of cortical microcircuits Main domain: Neurophysiology Nelson REBOLA ‘s team aims to understand how the diversity in synaptic properties found between communicating neurons shapes information processing in the brain. Presently the team is investigating how variability in biophysical properties and synaptic densities of a particular subtype of glutamate receptor, the NMDA receptor, in somatosensory neurons impacts the processing of sensory information. For more information
TEAM “Structural dynamics of networks”
Team leader(s)
CNS development and plasticity
Main domain : Cellular & molecular neurosciences

Nicolas RENIER’s plans to develop and use cutting-edge 3D whole brain imaging and genetic tools aimed at elucidating how neuronal networks in the adult brain can be rewired at a large scale.
The team will :
  • Investigate the molecular mechanisms of axon and branch dynamics in the adult brain
  • Gain new information on neuro-vascular interaction during plastic events
  • Develop correlative 3D imaging of live calcium imaging in the behaving animal with whole brain mapping of neuronal markers and connectivity
  • Determine the role of structural plasticity to support transitions in behavior in the mouse.
For more information
Team “Brain Development”
Team leader(s)
CNS development and plasticity Main domain : Cellular & molecular neurosciences Bassem HASSAN’s team investigates the formation of neurons and neural circuits during brain development, focusing on the transcriptional control of stem cells fate during early neurogenesis in Drosophila and mouse, and the emergence of individuality in Drosophila visual circuits and behavior. For more information
Team “Cellular physiology of cortical microcircuits”
Team leader(s)
Alberto BACCI PhD, DR1, CNRS
Main domain : Neurophysiology

Alberto Bacci’s team investigates the microcircuits of the cerebral cortex. In particular, the team is interested in the synaptic and plasticity properties of synapses originating from a highly diverse population of neurons forming stereotyped cortical circuits. To this aim, the lab uses a battery of ex vivo and in vivo neurophysiological approaches. For more information
Team “Genetics and physiopathology of epilepsy”
Team leader(s)
Eric LEGUERN MD, PhD, PU-PH, Sorbonne Université/APHP
Physiopathology of neurological disorders Main domain : Cellular & molecular neurosciences Subdomain : Clinical & translational neurosciences Stéphanie BAULAC & Eric LEGUERN’s team investigates the focal epilepsies linked to mTORC1 pathway, Focal cortical dysplasias, epileptic encephalopathies and genetic generalized epilepsies through three main aims:
  • To understand how mutations in the mTOR pathway genes contribute to epileptogenesis and seizures, and the role of brain somatic mutations
  • To characterize pathophysiological mechanisms of HCN1-epileptic encephalopathy, identify new genetic causes of fever-sensitive epileptic encephalopathies, and search for factors modulating the severity of the phenotype.
  • To explore how mutations found by the team in several presynaptic proteins lead to genetic generalized epilepsies (GGE).
For more information
Team “Alzheimer’s disease and prion diseases ”
Team leader(s)
Stephane HAIK MD, PhD, DR2, INSERM Contact by email
Marie-Claude POTIER PharmD, PhD, DR2, CNRS
Physiopathology of neurogical disorders
Main domain: Cellular & molecular neuroscience
Subdomain : Clinical & translational neurosciences

Marie-Claude Potier’s and Stéphane Haïk’s Team aims at understanding the role of lipids, particularly cholesterol and ApoE, in the secretion and neuronal transport, of AB, their involvement in endosomal modifications that occur early during the course of the disease and novel mechanisms of AB toxicity identified in vivo. For more information
Team “Control- Interoception – Attention”
Team leader(s)
Philippe FOSSATI MD, PhD, PU-PH, Sorbonne université, AP-HP
Goal directed behavior, social, moral cognition, motivation Main domain: Cognition Subdomain : Clinical & translational neurosciences Philippe FOSSATI & Liane SCHMIDT ’s team aims to understand how cognitive control processes integrate external and internal signals, and how this integration takes place on behavioral and neural levels, in healthy subjects and patients with impaired cognitive control (i.e., in depression and obesity). For more information
Team “Experimental neurosurgery”
Team leader(s)
Brian LAU PhD, CR1, CNRS
Carine KARACHI MD, PhD,MCU-PH, Sorbonne University, AP-HP
Basal ganglia, neurosurgery, movements disorders
Main domain: Neurophysiology
Subdomain: Clinical & translational neurosciences

Brain LAU & Carine KARACHI’s team aims to characterize the subcortico-cortical anatomy and physiology of brainnetworks involved in motor control, with the long-term goal of developing new therapies including novel applications of deep brain stimulation (DBS). For more information