Welcome to the Recruitment

POSITION

Context

Data Analysis Core facility (DAC) serves as a central hub for research data analysis and data management at the Paris Brain Institute, consisting of an enthusiastic team of experts in omics analysis, image analysis, machine learning, statistical methodology, and data management.

Job description

We are looking for people to support the implementation of the institute’s strategy to collect, process and publish data “as open as possible, as closed as necessary”. As the Open Science Officer, you will provide inperson support and be responsible for developing the documentation and guidelines to address the diversity of data collected at the institute. You will champion the institute’s strategy within national and international networks and ensure that the institute becomes a reference for practical, evidence-based data governance in neuroscience. In short, you will:

• Serve as the primary contact for researchers and support staff for FAIR data practices from
• collection to reuse, providing guidelines, documentation, and hands-on assistance for Data Management Plans.
• Educate and engage the local research community through workshops, training, and symposia.
• In close collaboration with the Chief Data Officer, provide specification and conduct usability testing for the development of data management solutions by the IT development team.
• Foster collaboration between research teams, CDO, IT department, RSSI, legal office, DPO, risk assurance, scientific integrity officer, and RIPH support.
• Participate in national and global initiatives in data management and open science, including INBS, FB, French Reproducibility Network, and RDA.
• Engage in data management collaborations with national and international research institutions toalign best practices and facilitate compliant data sharing.
• Address data governance issues with all stakeholders.
• Communicate and champion the institute’s open science strategy and accomplishments incollaboration with the scientific and medical affairs department, communication department, and institute leadership.

PROFILE

Know-how

• Experience in a research environment (academic or industry)
• Experience in implementing and advocating for data governance and open science for different stakeholders, including scientists, students, engineers, managers, and policy makers.
• Experience in creating educational resources, organizing training, workshops, and conferences.
• Experience in data protection regulations (GDPR), French health law, data protection assessments and regulatory ethical procedures (e.g., CNIL, APAFIS, CODECOH)

Knowledge

• PhD in (cognitive) neuroscience, biology or related field
• Broad understanding of best practices in data management across several data modalities in human and/or animal research, such as neuroimaging, microscopy, electrophysiology, cognitive tests, clinical research trial protocols, biological samples and sample preparations or sequencing data
• Understanding of digital solutions (software and tooling) for data management and (clinical) research databases (e.g., REDCap, LIMS, ELNs, OMERO, XNAT) desired but not required.
• Academic level in English (required) and conversational French (desired)

Soft skills

• Proven affinity for FAIR, open science practices, and personal data protection
• Proven organizational and project management skills.
• Proven ability to communicate with different stakeholders, respecting different background, needs, timetables, and expertise.
• Proven affinity animating and coordinating (inter)national networks in open science, data management or scientific reproducibility.
• Flexible, solution-oriented, with autonomy and initiative, and a hands-on attitude
• Excellent interpersonal skills

Conditions

• Starting date: as soon as possible
• Contract duration : permanent position (CDI).
• Remuneration: according to the level of study and experience.
• Location: Paris Brain Institute, Hôpital Pitié-Salpêtrière, 75013 PARIS.

Please send your resume and motivation letter (in English), indicating name and contact details of two references (incomplete applications will not be considered) to recrutement@icm-institute.org and stephen.whitmarsh@icm-institute.org  with the subject: “Open Science Officer”

POSTDOCTORAL FELLOW

CONTEXT

DBS: from genetic mutations to motor circuit dysfunctions & recovery – DBS is an exciting new interdisciplinary, collaborative, and multi-model project at the ICM. By bridging approaches across disciplines, the project aims to build novel strategies to improve dopaminergic cell survival and deep-brain stimulation of resilient circuits in Parkinson’s disease.

Collective Interest Projects – Collaborative, interdisciplinary, innovative & transformative – As part of DBS, we will implement the hiring of post-docs, each dedicated to one collective interest project to be co-supervised by two ICM team leaders, experts from different fields. The early-career researchers will receive training in fields that they have yet to receive training in, such as genetics, cellular physiology, imaging, optogenetics, behavior, or modeling.

We aim to attract high level interdisciplinary researchers by offering world class research facilities and double supervision from leaders in the relevant fields. You would be part of a dynamic community of young researchers within a highly collaborative environment.

In the project MAP-MODEL-MLR, the candidate will be hosted by Carine Karachi and Philippe Ravassard. Gait and

balance disorders are a major disability in Parkinson’s disease (PD) that is not effectively managed by traditional deep brain stimulation (DBS) or dopamine replacement. The mesencephalic locomotor region (MLR) is a promising target for new treatments, although development is limited by the lack of methods to activate specific MLR neurons driving locomotion. We aim to generate tools for developing cell-specific approaches in the MLR, based on the hypothesis that activating specific MLR glutamatergic neurons can ameliorate gait disorders in PD. In this interdisciplinary project, the candidate will be responsible for two main tasks. First, he/she will generate a neuroanatomical and cellular atlas of the MLR in monkey and human. Using a large panel of 2D and 3D histology methods detailed maps of the MLR will be defined including localization of neuronal cell bodies based on neurotransmitter identity. Spatial transcriptomics data within the studied region will be generated to provide refined molecular identity at the cellular level that will be aligned with the neuroanatomic data. Second, he/she will build a comprehensive single cell profile of chromatin accessibility to define promoter/enhancer elements that will be later used to control in a cell specific manner activation/modulation of specific glutamatergic MLR neurons as potential new treatment for PD.

MISSIONS

•  Generate neuroanatomical map of the MLR in monkey and human using 2D and 3D histological tools (immnunostaining and in situ hybridization)
• Perform spatial transcriptomics on MLR
• Generate single cell profiling of accessible chromatin using ATACseq
• Plan experiments, collect data, and analyze results.
• Organize tasks and participate in DBS project discussions.

CONDITIONS

• Remuneration scale: 35 000 – 45 000 € (gross annual)
• Fixed-term contract (CDD), renewable

PROFILE

KNOW-HOW

• Strong experience and technical skills to perform 2D and 3D histology.
• Ability to acquire high quality images using multiple microscopy equipment.
• Good autonomy within planning experimental protocols.
• Rigorous with data analysis.
• Ability to work in a project-based mode.

KNOWLEDGE

• Applicants must have a strong background in neuroanatomy. He/she must hold (or are expected to complete soon) a PhD or equivalent degree in biology, medicine or molecular biology.
• Experience with 2D and 3D histology methods, imaging and image analysis.
• Experience with omic data analysis and chromatin profiling.
• Excellent verbal and written communication skills in English are required.

SOFT SKILLS

• Accountability and commitment to collective goals.
• Integrity, honesty, and steadfast loyalty.
• Teamwork and solidarity, actively engaged in team welfare.
• Initiative, motivation, and inquisitiveness.
• Willingness to impart knowledge and promote good scientific practices with respect for individuals.
• Scientific rigor, meticulous attention to detail, excellent organizational skills, precision, and discipline.

The Paris Brain Institute is committed to combating all forms of discrimination. We guarantee an inclusive and respectful working environment that embraces all diversities.

All our positions are open to people with disabilities.

Please send your CV, letter of motivation and 2 reference letters with contact details to
carine.karachi@icm-institute.org, philippe.ravassard@icm-institute.org and joana.guedes@icminstitute.org with the subject: “DBS CIP MAP-MODEL-MLR Post-doc (M/F).”

Please send your CV to recrutement@icm-institute.org with the subject: “DBS CIP MAP-MODEL-MLR Post-doc (M/F).”

POSTDOCTORAL FELLOW

CONTEXT

DBS: from genetic mutations to motor circuit dysfunctions & recovery – DBS is an exciting new interdisciplinary, collaborative, and multi-model project at the ICM. By bridging approaches across disciplines, the project aims to build novel strategies to improve dopaminergic cell survival and deep-brain stimulation of resilient circuits in Parkinson’s disease.

Collective Interest Projects – Collaborative, interdisciplinary, innovative & transformative – As part of DBS, we will implement the hiring of post-docs, each dedicated to one collective interest project to be co-supervised by two ICM team leaders, experts from different fields. The early-career researchers will receive training in fields that they have yet to receive training in, such as genetics, cellular physiology, imaging, optogenetics, behavior, or modeling.

We aim to attract high level interdisciplinary researchers by offering world class research facilities and double supervision from leaders in the relevant fields. You would be part of a dynamic community of young researchers within a highly collaborative environment.

In the project Behavioral homology: Effect of dopamine on variability of motor patterns in fish and humans the candidate will be hosted by the Experimental Neurosurgery team and SIBBIL team, co-supervised by Dr. Marco Romanato, expert in instrumented human motion analysis, working in the lab of Prof. Marie-Laure Welter, an MD expert in human walking and deep brain stimulation in Parkinson’s disease, and Dr. Antonio Carlos Costa, an expert in data-driven approaches to behavioral dynamics, working in the lab of Dr. Claire Wyart, an expert in optogenetics and imaging in zebrafish. The postdoctoral fellow will develop computational approaches for the unsupervised quantification of Parkinsonism from high resolution movement data. The first goal will be to quantify the role of dopamine on posture and navigation in larval zebrafish, building upon custom analysis approaches. Subsequently, the aim will be to extend this analysis of human gait dynamics to dissect the effect of different therapeutic strategies on Parkinsonism. The postdoctoral fellow will develop computational frameworks for quantifying the multiple scales of behavioral dynamics and analyzing gait cycle stability at different levels of Parkinsonism.

MISSIONS

• Analysis of posture data in zebrafish and human patients in different Parkinson’s conditions and therapies
• Supervision of engineers and graduate students in the SIBBIL and Experimental Neurosurgery teams
• The position will be held in the Paris Brain Institute

CONDITIONS

• Remuneration scale: 35 000 – 45 000 € (“brut annuel”)
• Fixed-term contract (CDD)
• The position comes with 10 000 euros available for training

PROFILE

KNOW-HOW

• Expertise in non-linear dynamics, information theory and/or computational physics
• Supervision of technicians, students and/or engineers
• PhD in physics, biophysics, mathematics, neuroscience, engineering
• Academic reading, writing, and conversational skills in English (required) and French (desired)

KNOWLEDGE

• Knowledge acquired through education in Physics, Neuroscience, Engineering
• Fluent in English, notions of French
• Knowledge in coding using Python, Matlab, Julia
• Organized, disciplined, proactive, autonomous, excellent team player
• Training in non-linear dynamics and statistical mechanics

SOFT SKILLS

• Rigorous, communicative, curious to understand and broaden her/his field of expertise
• Excellent team player working with engineer, technicians and other postdocs in the DBS project
• Autonomy in thinking new paradigms and analyzing new data
• Excellent communication both oral and written

The Paris Brain Institute is committed to combating all forms of discrimination. We guarantee an inclusive and respectful working environment that embraces all diversities.

All our positions are open to people with disabilities.

Please send your CV, letter of motivation and 2 reference letters with contact details to antonio.costa@icm-institute.org, marielaure.welter@icm-institute.org, and joana.guedes@icm-institute.org with the subject: “DBS UnstablePeriodicOrbit CIP Post-doc (M/F)”

Please send your CV to recrutement@icm-institute.org with the subject: “DBS UnstablePeriodicOrbit CIP Post-doc (M/F)”

POSTDOCTORAL FELLOW

CONTEXT

DBS: from genetic mutations to motor circuit dysfunctions & recovery – DBS is an exciting new interdisciplinary, collaborative, and multi-model project at the ICM. By bridging approaches across disciplines, the project aims to build novel strategies to improve dopaminergic cell survival and deep-brain stimulation of resilient circuits in Parkinson’s disease.

Collective Interest Projects – Collaborative, interdisciplinary, innovative & transformative – As part of DBS, we will implement the hiring of post-docs, each dedicated to one collective interest project to be co-supervised by two ICM team leaders, experts from different fields. The early-career researchers will receive training in fields that they have yet to receive training in, such as genetics, cellular physiology, imaging, optogenetics, behavior, or modeling.

We aim to attract high level interdisciplinary researchers by offering world class research facilities and double supervision from leaders in the relevant fields. You would be part of a dynamic community of young researchers within a highly collaborative environment.

In the SUSCEPTDopamine project, the candidate will be hosted by the teams of Jaime de Juan Sanz and Nelson Rebola. This project aims to create a conceptual and experimental framework to understand the preferential susceptibility of dopaminergic neurons to impaired mitochondrial physiology, leveraging the strong genetic link between mitochondrial dysfunction and Parkinson’s Disease (PD). Our proposal seeks to dissect the mechanisms by which Ca2+-mediated adjustments of mitochondrial metabolism support neurotransmission in intact tissue, with a particular focus on understanding why dopaminergic signaling is preferentially affected by mitochondrial dysfunction.

MISSIONS

• Perform whole-cell electrophysiological experiments on acute brain slices or cultured cells.
• Conduct live imaging (confocal or two-photon) of genetically encoded neurotransmitter sensors from acute or cultured preparations.
• Use of Optogenetics.
• Plan experiments, collect data, and analyze results.
• Organize tasks and participate in DBS project discussions.
• All equipment and resources are already available in the host teams.

CONDITIONS

• Remuneration scale: 35 000 – 45 000 € (gross annual)
• Fixed-term contract (CDD), renewable

PROFILE

KNOW-HOW

• Use of tools/equipment: Brain slicer, dissection equipment, Fluorescence microscope, patch clamp amplifier.
• Strongly encouraged to have experience in cellular neurophysiology.
• Capable of supervising students.
• Minimum of 5 years of professional experience.
• Good autonomy within planning experimental protocols, proactive, team player.
• Rigorous with data analysis.
• Ability to work in a project-based mode.
• Proficient reading, writing, and conversational skills in scientific English (required).
• Ability to program in python is a strong added value.

KNOWLEDGE

• Knowledge in neurophysiology, synaptic transmission, cellular neuroscience, neuronal function.
• Rigorous, organized, and swift scientific writing with dexterity, conciseness, and precision.
• Proficiency in the use of software to electrophysiological and/or imaging data including python, FIJI, etc.
• Ability to summarize results.
• PhD in Neuroscience or associated disciplines.

SOFT SKILLS

• Sense of responsibility and collective interest.
• Integrity, honesty, and loyalty.
• Team spirit and solidarity, socially engaged and invested in the team’s well-being.
• Proactivity, motivation, and curiosity.
• Desire to share knowledge and train others in good scientific practices that respect individuals.
• Scientific rigor, attention to detail, strong organizational skills, conciseness, precision, and discipline.

The Paris Brain Institute is committed to combating all forms of discrimination. We guarantee an inclusive and respectful working environment that embraces all diversities.

All our positions are open to people with disabilities.

Please send your CV, letter of motivation and 2 reference letters with contact details to nelson.rebola@icm-institute.org,  jaime.dejuansanz@icm-institute.org and joana.guedes@icm-institute.org with the subject: “DBS CIP SUSCEPTDopamine Post-doc (M/F)”.

Please send your CV to recrutement@icm-institute.org with the subject: “DBS CIP SUSCEPTDopamine Post-doc (M/F)”.

POSTDOCTORAL FELLOW

CONTEXT

DBS: from genetic mutations to motor circuit dysfunctions & recovery – DBS is an exciting new interdisciplinary, collaborative, and multi-model project at the ICM. By bridging approaches across disciplines, the project aims to build novel strategies to improve dopaminergic cell survival and deep-brain stimulation of resilient circuits in Parkinson’s disease.

Collective Interest Projects – Collaborative, interdisciplinary, innovative & transformative – As part of DBS, we will implement the hiring of post-docs, each dedicated to one collective interest project to be co-supervised by two ICM team leaders, experts from different fields. The early-career researchers will receive training in fields that they have yet to receive training in, such as genetics, cellular physiology, imaging, optogenetics, behavior, or modeling.

We aim to attract high level interdisciplinary researchers by offering world class research facilities and double supervision from leaders in the relevant fields. You would be part of a dynamic community of young researchers within a highly collaborative environment.

In the Collective Interest Project “Knock-in Fish: Knocking-in dominant mutations causing early-onset Parkinsonism in zebrafish” the candidate will be hosted by the Picnic team and SIBBIL team co-supervised by Claire Wyart, an expert in optogenetics and imaging in zebrafish and Jacobo Sitt, expert in the analysis of large neuronal networks and behavior in humans.

Supervised by these teams, the postdoctoral fellow will require autonomy to innovate novel fish knock-in lines in which a single base is edited to mimic a mutation associated with early onset parkinsonism. The postdoctoral fellow will first generate the knock in mutation by advising engineers and technicians, and then will test the effects of the mutation on motor control and behavior, as well as on dopaminergic neurons and their roles in neuronal network dynamics within motor circuits.

The project will focus on the knock-in of the very conserved gene PPP2R5D, a very interesting target that has been involved in mental retardation and early onset Parkinsonism. The postdoc will work and supervise engineers to generate knock-in mimicking point mutations in humans.

MISSIONS

• Develop an in vivo project linking PPP2R5D mutations to motor defects in zebrafish larvae
• Supervise technicians and engineers in the SIBBIL team to generate the molecular tools
• The position comes with 10 000 euros available for training per year

CONDITIONS

• Remuneration scale: 35 000 – 45 000 € (gross annual), based on experience
• Fixed-term contract (CDD), renewable, with possibility of extension to ensure high quality publication of the postdoctoral work

PROFILE

KNOW-HOW

• Expertise in genetics & behavioral analysis
• Expertise in fluorescent imaging and image analysis
• At ease with hypothetico-deductive and critical reasoning
• Experience with big data analysis, statistical analysis
• Supervision of technicians, students and / or engineers
• Big data analysis from gene to behavior embracing variability
• Academic reading, writing, and conversational skills in English

KNOWLEDGE

• Knowledge acquired through education in Neuroscience, Genetics, Biophysics, Dynamic Imaging
• Fluent in English & at ease for bringing concepts forward
• Knowledge in coding using Python, R and/or MATLAB
• Organized, disciplined, proactive, autonomous, excellent team player
• PhD in neuroscience, genetics
• Strong training in rational reasoning

SOFT SKILLS

• Discipline and organization
• Proactive attitude with leadership skills to provide clear guidance to engineers in team and facilities
• Sense of priority to organize experiments and perform experiments straight on target
• Rigorous, communicative, honest and curious to understand and broaden her/his field of expertise
• Excellent team player working with engineers, technicians and other postdocs in the DBS project
• Autonomy in setting up new experiments, thinking new paradigms and analyzing new data
• Excellent written communication combined with oral skills

The Paris Brain Institute is committed to combating all forms of discrimination. We guarantee an inclusive and respectful working environment that embraces all diversities.

All our positions are open to people with disabilities.

Please send your CV, letter of motivation and 2 reference letters with contact details to claire.wyart@icm-institute.org , jacobo.sitt@icm-institute.org and joana.guedes@icm-institute.org with the subject: “DBS CIP Knock-in Fish Post-doc (M/F)”

Please send your CV to recrutement@icm-institute.org with the subject: “DBS CIP Knock-in Fish Post-doc (M/F)”

POSTDOCTORAL FELLOW

CONTEXT

DBS: from genetic mutations to motor circuit dysfunctions & recovery – DBS is an exciting new interdisciplinary, collaborative, and multi-model project at the ICM. By bridging approaches across disciplines, the project aims to build novel strategies to improve dopaminergic cell survival and deep-brain stimulation of resilient circuits in Parkinson’s disease.

Collective Interest Projects – Collaborative, interdisciplinary, innovative & transformative – As part of DBS, we will implement the hiring of post-docs, each dedicated to one collective interest project to be co-supervised by two ICM team leaders, experts from different fields. Early-career researchers will receive training in fields that they have yet to receive training in, such as genetics, cellular physiology, imaging, optogenetics, behavior, or modeling.

To attract high-level interdisciplinary researchers, we offer world-class research facilities and double supervision from leaders in the relevant fields. You would be part of a dynamic community of young researchers within a highly collaborative environment. In the project FUST: Fish Ultrasound screening of optimal channels to STimulate neurons deep in vivo, the candidate will be hosted by the Mov’it team and SIBBIL team, co-supervised by Pierre Pouget, an expert in functional ultrasounds and network physiology, and Claire Wyart, an expert in optogenetics and imaging. Supervised by these 2 teams to activate specific neurons in the mammalian brain, the postdoctoral fellow will require autonomy to innovate sonogenetic tools leveraging mechanosensory activation for remote neuronal stimulation in the brain. The postdoctoral fellow will first implement an ultrasound screening assay to identify the best candidate channels to mediate remote ultrasound activation without heating and then test them in vivo at different depths while measuring the specific and non-specific responses to ultrasounds.

MISSIONS

• Screening of channels responding to ultrasounds in cell cultures and in vivo using zebrafish larvae
• The postdoctoral fellow will supervise engineers in the SIBBIL and Mov’it teams.
• The position will be held in the Paris Brain Institute with scheduled visits in biophysics lab of Francesco Tombola in University of California in Irvine (https://www.faculty.uci.edu/profile/?facultyId=5609), a world expert on ion channels & mechanoreception
• The position comes with 10 000 euros available for training.

CONDITIONS

• Remuneration scale: 35 000 – 45 000 € (“brut annuel”)
• Fixed-term contract (CDD) renewable

PROFILE

KNOW-HOW

• Expertise in molecular cloning and channel physiology in vitro
• Supervision of technicians, students, and / or engineers
• PhD in biophysics, electrophysiology, imaging, neuroscience
• Academic reading, writing, and conversational skills in English (required) and French (desired)

KNOWLEDGE

• Knowledge acquired through education in Biophysics, Neuroscience, Dynamic Imaging
• Fluent in English, notions of French
• Knowledge of coding using Python, R
• Organized, disciplined, proactive, autonomous, excellent team player
• PhD in biophysics, bonus: expert on ion channel physiology
• Strong training in electrophysiology, at ease in mathematics and calculation of conductance and IV curves

SOFT SKILLS

• Rigorous, communicative, and curious to understand and broaden her/his field of expertise
• Excellent team player working with engineers, technicians, and other postdocs in the DBS project
• Autonomy in setting up new experiments, thinking of

The Paris Brain Institute is committed to combating all forms of discrimination. We guarantee an inclusive and respectful working environment that embraces all diversities.

All our positions are open to people with disabilities.

Please send your CV, letter of motivation and 2 reference letters with contact details to claire.wyart@icm-institute.org , pierre.pouget@icm-institute.org and joana.guedes@icm-institute.org with the subject: “DBS CIP FUST Post-doc (M/F)”

Please send your CV to recrutement@icm-institute.org with the subject: “DBS CIP FUST Post-doc (M/F)”

CONTEXT

DBS: from genetic mutations to motor circuit dysfunctions & recovery DBS is an exciting new interdisciplinary, collaborative, and multi-model project at the ICM.
By bridging approaches across disciplines, the project’s goal is to build novel strategies to
improve dopaminergic cell survival and deep-brain stimulation of resilient circuits in
Parkinson’s disease.
Collective Interest Projects – Collaborative, interdisciplinary, innovative & transformative
As part of DBS, we will implement the hiring of post-docs each dedicated to one collective interest project to be cosupervised by two ICM team leaders, experts from different fields. The early-career researchers will receive training in the field that they have not received training on yet, either genetics, cellular physiology, imaging, optogenetics, behavior or modelling.
We aim to attract high level interdisciplinary researchers by offering world class research facilities and double supervision from leaders in the relevant fields. You would be part of a dynamic community of young researchers within a highly collaborative environment.
The CorticalMLR project, led by Alberto Bacci and Nelson Rebola, focuses on characterizing the functional diversity of neurons within the mesencephalic locomotor region (MLR). Deep brain stimulation (DBS) targeting the MLR has been employed in treating Parkinsonism with varying success rates. Recent hypotheses suggest that the heterogeneous outcomes may stem from the diverse cellular composition within the MLR. Furthermore, the mechanisms linking DBS in the MLR to gait control remain incompletely understood. This interdisciplinary project employs electrophysiological and optogenetic techniques to comprehensively assess the functional diversity of MLR neurons in vivo. The objective is to elucidate how ascending feedback information from the different MLR nuclei control the emergence of internal states in the neocortex linked to distinct active behavioral states, particularly locomotion. We expect to contribute to a better understanding of MLR circuit diversity with the potential improvement of the design of new DBS strategies.

MISSIONS

• Perform in vivo electrophysiological experiments from awake animals.
• Manipulate activity of neuronal circuits in vivo using optogenetics.
• Plan experiments, collect data, and analyze results.
• Stereotaxic viral injections.
• Organize tasks and participate in DBS project discussions.
• All equipment and resources are already available in the host teams.

CONDITIONS

• Remuneration scale: 35 000 – 45 000 € (gross annual)
• one year – Fixed-term contract (CDD), renewable

PROFILE

KNOW-HOW

• Use of tools/equipment: Neuropixel probes, dissection equipment, LED manipulation for optogenetic
experiments, brain slicer for histochemical validation of recording sites.
• Strongly encouraged to have experience in cellular neurophysiology and or systems neuroscience.
• Capable of supervising students.
• Minimum of 5 years of professional experience.
• Good autonomy within planning experimental protocols, proactive, team player.
• Rigorous with data analysis.
• Ability to work in a project-based mode.

KNOWLEDGE

• Applicants must have a background in neuroscience. They must hold (or are expected to complete soon) a PhD or
equivalent degree in biology, medicine, physics or bioengineering.
• Excellent verbal and written communication skills in English are required.
• Experience with in vivo electrophysiology, imaging and/or computational neuroscience is appreciated but not
required.
• Coding knowledge is appreciated.

SOFT SKILLS

• Accountability and commitment to collective goals.
• Integrity, honesty, and steadfast loyalty.
• Teamwork and solidarity, actively engaged in team welfare.
• Initiative, motivation, and inquisitiveness.
• Willingness to impart knowledge and promote good scientific practices with respect for individuals.
• Scientific rigor, meticulous attention to detail, excellent organizational skills, precision, and discipline.

The Paris Brain Institute is committed to combating all forms of discrimination. We guarantee an inclusive and respectful working environment that embraces diversity.
All our positions are open to people with disabilities.

Please send your CV, letter of motivation and 2 reference letters with contact details to
nelson.rebola@icm-institute.org , alberto.bacci@icm-institute.org and joana.guedes@icminstitute.org with the subject: “DBS CIP CorticalMLR Post-doc (M/F)

CONTEXT

DBS: from genetic mutations to motor circuit dysfunctions & recovery

DBS is an exciting new interdisciplinary, collaborative, and multi-model project at the ICM.
By bridging approaches across disciplines, the project’s goal is to build novel strategies to
improve dopaminergic cell survival and deep-brain stimulation of resilient circuits in
Parkinson’s disease.
Collective Interest Projects – Collaborative, interdisciplinary, innovative & transformative
As part of DBS, we will implement the hiring of post-docs each dedicated to one collective interest project to be cosupervised by two ICM team leaders, experts from different fields. The early-career researchers will receive training in the field that they have not received training on yet, either genetics, cellular physiology, imaging, optogenetics, behavior or
modelling.
We aim to attract high level interdisciplinary researchers by offering world class research facilities and double supervision from leaders in the relevant fields. You would be part of a dynamic community of young researchers within a highly collaborative environment.
In the LysoPDCalcium project, the candidate will be hosted by the teams of Jaime de Juan-Sanz and Dafni Hadjieconomou. This project aims to address the urgent need to understand lysosomal Ca2+ dysregulation in Parkinson’s Disease (PD), an area that is critical yet poorly explored. Our proposal aims to develop LysoCaMPs, innovative optical tools for the direct measurement of lysosomal Ca2+, which will provide crucial insights into synaptic physiology and neuronal activity. This project will apply these tools both in iPSC-derived neurons and in vivo models using Drosophila, to uncover the mechanisms by which Ca2+-mediated adjustments of mitochondrial metabolism support neurotransmission and contribute to PD pathology.

MISSIONS

• Transgenic Fly Generation, extensive experience working with Drosophila melanogaster
• Lysosomal Targeting, Chemical Ligand Delivery
• In Vivo Imaging
• Lysosomal Ca2+ Analysis
• Drosophila Behavioral Assays
• Data Analysis
• Collaborative Research
• Plan experiments, collect data, and analyze results.
• Organize tasks and participate in DBS project discussions.

CONDITIONS

• Remuneration scale: 35 000 – 45 000 € (gross annual)
• Fixed-term contract (CDD), renewable

PROFILE

KNOW-HOW

• Capable of supervising students.
• Good autonomy within planning experimental protocols, proactive, team player.
• Rigorous with data analysis.
• Ability to work in a project-based mode.
• Proficient reading, writing, and conversational skills in scientific English (required).

KNOWLEDGE

• Drosophila Genetics
• Molecular Biology
• Brain-Gut Axis in Drosophila
• Behavioral Assays in Drosophila
• Rigorous, organized, and swift scientific writing with dexterity, conciseness and precision.
• Proficiency in the use of software to electrophysiological and/or imaging data including python, FIJI, etc.
• Ability to summarize results.
• PhD in Neuroscience or associated disciplines.

SOFT SKILLS

• Sense of responsibility and collective interest.
• Integrity, honesty, and loyalty.
• Team spirit and solidarity, socially engaged and invested in the team’s well-being.
• Proactivity, motivation, and curiosity.
• Desire to share knowledge and train others in good scientific practices that respect individuals.
• Scientific rigor, attention to detail, strong organizational skills, conciseness, precision, and discipline.

The Paris Brain Institute is committed to combating all forms of discrimination. We guarantee an inclusive and respectful working environment that embraces diversity.
All our positions are open to people with disabilities.

Please send your CV, letter of motivation and 2 reference letters with contact details to
jaime.dejuansanz@icm-institute.org, dafni.hadjieconomou@icm-institute.org and
joana.guedes@icm-institute.org with the subject: “DBS CIP LysoPDCalcium Post-doc (M/F)”

POSITION

We are offering a post-doctoral position in the team “Molecular Pathophysiology of Parkinson’s disease”, at the Paris Brain Institute. The project focuses on the analysis and characterization of ligands of aggregating proteins. It is a full-time employment contract for an initial employment period of 2 years. The postdoctoral researcher will join our dynamic international team but also work with a group of European partners on this project.

PROFILE

We are seeking a highly motivated individual with a strong background in biochemistry and neuroscience, particularly in the study of protein aggregation, protein-protein interactions and protein-RNA interactions. Ideal candidates will possess the following qualifications & skills:

–  PhD in Biochemistry or Neuroscience

–  Research Interest: Demonstrated strong interest in protein aggregation research through publications and references from the candidate’s thesis advisor

–  Technical Experience: in vitro aggregation, protein-protein interaction, characterization of amyloid structures, RNA binding proteins biology, structural biology and cellular biology.

–   Research Motivation: High level of motivation for both independent and collaborative research,

–   Language Skills: Fluency in English, both written and spoken

–   Interpersonal Skills: Rigorous and committed, you have a sense of relationship, service to users and teamwork, you are autonomous

CV to be sent to: recrutement@icm-institute.org indicating “Postdoc NSBC (m/f)”

POSITION

Context

The Paris Brain Institute engages increasingly in large multi-cohort, multi-central transversal clinical research studies that aim to allow integrated data exploration and prediction models across diverse sets of retrospective and prospective clinical research databases, integrating multimodal data from neuroimaging, biological samples, and omics. These studies require long-term solutions that ensure interoperability across the diversity of research data. The Data Analysis Core facility (DAC) supports researchers throughout this process by providing robust and reproducible analysis and data management solutions. If you are interested in data, biology and neuroscience and want to contribute to discoveries in a stimulating research environment, the DAC could be the place for you.

Missions

We are currently looking for data managers to help us manage a diversity of clinical data collected and analyzed at the institute, as part of multimodal studies that integrate neuroimaging, microscopy, electrophysiology, behavior data and biological samples. You will be responsible for designing electronic data capture within REDCap in close collaboration with research teams, data acquisition platforms, project managers and engineers, under the supervision and – supported by – our clinical research data manager. You will be part of ambitious programs aimed at discovering new insights and treatments for neurological diseases and neurodegenerative disorders, by reinforcing Good Clinical Practices in data science within a transversal team that includes IT, Legal office, Data Protection Officer, support for human studies (RIPH), and risk assurance. Your tasks will include:

• Using REDCap to design eCRFs.
• Design and perform quality control of large cohort clinical research databases using built-in solutions and where needed develop your own.
• Administrate and perform maintenance on REDCap databases.
• Implement solutions to ensure consistency of REDCap databases with multi-modal data, including neuroimaging and multi(omics).
• Implement harmonization and interoperability across (retrospective) clinical research databases.
• Optimize user-interfaces in REDCap.
• Document processes, including guidelines for clinical research data management.

PROFILE

Know-how

• Hands-on experience in the use and configuration of REDCap or other eCRF systems (highly desired)
• Experience in Good Clinical Practices (GCP), i.e. Bonnes Pratiques Cliniques (BPC)
• Programming experience in markup languages desired, especially in HTML
• Professional experience in a research environment (academic or industry)
• Understanding digital tools for data management and (clinical) research databases (e.g., REDCap, CDISC)
• Understanding of clinical research ontologies (e.g. BioPortal, FHIR)
• English and/or French language skills

Knowledge

• Master’s degree or higher in data management, bioinformatics, biotechnology, or related field

Soft skills

• Autonomy and initiative, with a hands-on attitude
• Excellent organizational and project management skills
• Flexible and solution-oriented with the ability to communicate with researchers and staff from different backgrounds and with different needs, timetables, and understanding.

Conditions

• Remuneration: according to the level of study and experience

Please send your CV and letter of motivation (in English), indicating name and contact details of two references (incomplete dossiers will not be considered) to recrutement@icm-institute.org and stephen.whitmarsh@icm-institute.org with the subject: “Clinical Research Data Manager M/F”.

POSITION

The Paris Brain Institute (Institut du Cerveau) is recruiting a Clinical trial Assistant for its industrial clinical research unit « Neurotrials » and its academic clinical research support unit « Cellule Support RIPH ».
Within the Institute, the Neurotrials unit is a CRO-type early-stage clinical research unit for the design, management and conduct of phase Ib/IIa clinical trials, with industrial sponsorship, in drug development or in the field of medical devices. In addition to its Neurotrials unit, the Institute has also created a unit dedicated to supporting research involving human subjects (RIPH) for institutional (ICM) sponsorship as part of its contribution to clinical research.

MAIN JOB DUTIES

• General office organization, including reception coverage, ordering supplies, shipping, managing inventory, etc.;
• Perform administrative duties in conformity with internal policies and procedures;
• Provide day-to-day project support activities – maintenance of project-related files, such as maintenance of TMF, document naming and versioning, creation of hyperlinks;
• Assist the team with the preparation, formatting, handling, distribution, and filing of clinical documentation and reports according to the scope of work and standard operating procedures
• Coordinate internal and with sponsor/partner meetings, attend relevant clinical study meetings as deemed appropriate and provide meeting minutes.
• Set up and organize events, schedule appointments, make travel arrangements for staff/ visitors;
• Maintain databases/spreadsheets as necessary to facilitate tracking/documentation of the Neurotrials unit activities;
• Arrange the signing process of documents in conjunction with relevant departments within the Institute and/or partners or clients;
• Coordination of PR communication activities;
• Perform other administrative tasks as needed.

PROFILE

• A high school diploma (bachelor’s degree preferred); Fluent (Proficiency) both in French and English;
• At least 1 year of assistant experience (CTA experience preferred);
• Excellent organizational and prioritization skills;
• Time management and multitasks abilities;
• Proficiency in Microsoft Office Package;
• Attention to detail and excellent oral and written communication skills.
• Excellent social and teamwork skills

Apply to: recrutement@icm-institute.org indicating « Clinical Trial Assistant »