Recruitment

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Senior bioinformatician (M/F) Positions to be filled : Soon as possible Type of job : Permanent contract Type of activity : Scientific teams Ad type : ICM

POSITION

Context

The Data Analysis Core facility (DAC) is a core facility of the Paris Brain Institute that supports researchers in the discovery of new insights and treatments in the field of neurological diseases and disorders. The DAC consists of an enthusiastic interdisciplinary team of experts in biostatistics, bioinformatics, image analysis, and data managers. We accompany researchers throughout the research cycle, by providing robust and reproducible analyses, expert advice, training, and the development of new solutions for emerging technologies. If you are interested in the brain and want to contribute to discoveries in a stimulating research environment, the DAC could be the place for you.

 

Missions

We are looking for senior bioinformatician to reinforce our ability to tackle the questions of today. The fast-evolving field requires initiative to find solutions, and a sensitivity to quality control, communication with research teams, and teamwork. Technical expertise and experience in several omics modalities are needed to meet the increasingly complex and multimodal bioinformatics approaches. As a member of our omics analysis team, you will be responsible for the translation of biological questions into actionable insights through bioinformatics analyses. You will be expected to be independent in managing multiple projects simultaneously, ensuring quality through regular rapports and communication with research teams under the supervision of our omics team manager and supported by the team’s project manager.

  • Provide support to research teams in the analysis and interpretation of (multi)omics data, including (but not limited to) scRNAseq and Spatial Transcriptomics.
  • Participate in developments of bioinformatics pipelines and workflows for (multi)omics data analysis, ensuring accuracy, reproducibility, and scalability.
  • Collaborate with computational biologists, geneticists, and clinicians to integrate (multi)omics data and facilitate translational research efforts.
  • Stay updated with the latest advancements in omics technologies, bioinformatics tools, and analytical methods, and contribute to the continuous improvement of data analysis workflows.

 

 

PROFILE

 

Know-how

  • Expertise in the analysis of several omics data types, e.g. spatial transcriptomics, single-cell and/or bulk RNA sequencing, single-cell and/or bulk ATAC sequencing, proteomics, WGS/WES sequencing, methylation data, CHIPseq.
  • Experience in complex experimental designs, e.g. non-custom references, multi-omics data integration, and integration of multiple variables in bulk designs.
  • Proficiency in UNIX environments (shell).
  • Proficiency in R (required), and Python (desired), in a version-controlled setting (Git).
  • Proficiency in data visualization.
  • Professional experience of at least four years in the field of omics analysis in academia or industry.
  • Proven experience in routine and complex omics analyses.
  • Proven experience in communicating and interpreting results for researchers/biologists.
  • Academic reading, writing, and conversational skills in English (required) and French (desired).

 

Knowledge

  • Minimum Bac+5 (master or engineer) in bioinformatics, or equivalent level in biology/computing.
  • Training in omics analyses, including but not limited to, batch effect correction, differential expression, pathways enrichment, trajectory analyses, and deconvolution.

 

Soft skills

  • Ability to work in a team according to common procedures.
  • Autonomy, initiative, and flexibility in finding solutions for new and unexpected issues.
  • Ability to communicate with people from various scientific and technical backgrounds.
  • Motivation to advance research in neuroscience!

 

Conditions

  • Remuneration: according to the level of study and experience.

 

 

Please send your CV and letter of motivation (in English), indicating name and contact details of two references (incomplete dossiers will not be considered) to recrutement@icm-institute.org and marie.coutelier@icm-institute.org with the subject: “Senior bioinformatician (M/F)”.

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Clinical Research Data Manager (M/F) Positions to be filled : Soon as possible Type of job : Permanent contract Type of activity : Scientific teams Ad type : ICM

POSITION

Context

The Paris Brain Institute engages increasingly in large multi-cohort, multi-central transversal clinical research studies that aim to allow integrated data exploration and prediction models across diverse sets of retrospective and prospective clinical research databases, integrating multimodal data from neuroimaging, biological samples, and omics. These studies require long-term solutions that ensure interoperability across the diversity of research data. The Data Analysis Core facility (DAC) supports researchers throughout this process by providing robust and reproducible analysis and data management solutions. If you are interested in data, biology and neuroscience and want to contribute to discoveries in a stimulating research environment, the DAC could be the place for you.

 

Missions

We are currently looking for data managers to help us manage a diversity of clinical data collected and analyzed at the institute, as part of multimodal studies that integrate neuroimaging, microscopy, electrophysiology, behavior data and biological samples. You will be responsible for designing electronic data capture within REDCap in close collaboration with research teams, data acquisition platforms, project managers and engineers, under the supervision and – supported by – our clinical research data manager. You will be part of ambitious programs aimed at discovering new insights and treatments for neurological diseases and neurodegenerative disorders, by reinforcing Good Clinical Practices in data science within a transversal team that includes IT, Legal office, Data Protection Officer, support for human studies (RIPH), and risk assurance. Your tasks will include:

  • Using REDCap to design eCRFs.
  • Design and perform quality control of large cohort clinical research databases using built-in solutions and where needed develop your own.
  • Administrate and perform maintenance on REDCap databases.
  • Implement solutions to ensure consistency of REDCap databases with multi-modal data, including neuroimaging and multi(omics).
  • Implement harmonization and interoperability across (retrospective) clinical research databases.
  • Optimize user-interfaces in REDCap.
  • Document processes, including guidelines for clinical research data management.

 

 

PROFILE

 

Know-how

  • Hands-on experience in the use and configuration of REDCap or other eCRF systems (highly desired)
  • Experience in Good Clinical Practices (GCP), i.e. Bonnes Pratiques Cliniques (BPC)
  • Programming experience in markup languages desired, especially in HTML
  • Professional experience in a research environment (academic or industry)
  • Understanding digital tools for data management and (clinical) research databases (e.g., REDCap, CDISC)
  • Understanding of clinical research ontologies (e.g. BioPortal, FHIR)
  • English and/or French language skills

 

Knowledge

 

  • Master’s degree or higher in data management, bioinformatics, biotechnology, or related field

 

Soft skills

  • Autonomy and initiative, with a hands-on attitude
  • Excellent organizational and project management skills
  • Flexible and solution-oriented with the ability to communicate with researchers and staff from different backgrounds and with different needs, timetables, and understanding.

 

Conditions

  • Remuneration: according to the level of study and experience

 

 

Please send your CV and letter of motivation (in English), indicating name and contact details of two references (incomplete dossiers will not be considered) to recrutement@icm-institute.org and stephen.whitmarsh@icm-institute.org with the subject: “Clinical Research Data Manager M/F”.

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Ph.D. student positions Positions to be filled : 01/01/2024 Type of job : Fixed term contract Type of activity : Scientific teams Ad type : ICM

We invite applications for Ph.D. students to join our team Neuronal Circuits & Brain Dynamics at the Paris Brain Institute (ICM) to study the principles of neuronal circuit organization and brain dynamics.
If you are fueled by motivation, enthusiasm, and an insatiable curiosity, interested in
experimental or computational systems and circuits neuroscience, and seeking an environment that nurtures your potential, encourages collaboration, and provides exceptional research opportunities, we invite you to consider joining our lab.
Our team values diversity and welcomes researchers from all backgrounds and profiles.
If your project ideas align with our research focus, we encourage you to get in touch with us.

Research Topics

We are interested in how neuronal circuits are organized and how the collective action of
neurons gives rise to the emergent complex brain dynamics and behavior. We focus on how neurochemicals and bodily signals influence the brain.
▪ We study how the simultaneous release of neuromodulators influences the activity of
neurons and the coordination of brain regions
▪ We also study how bodily signals, such as breathing, serve as fundamental elements of
the oscillatory circuit architecture
▪ We employ our approach to study the brain dynamics during behavior and sleep and
their involvement in the transformation of fleeting experiences into long-term memories
To answer these fundamental questions about the nature and function of the brain, we combine a range of cutting-edge neurotechnologies that enable us to observe and control the activity of the brain. We aim to identify and explore the fundamental principles of neural circuit organization and apply our understanding for the improvement of the human condition.
Pure experimental, as well as computational/theoretical, or hybrid projects are available,
depending on your interest and skills.

Profile

We are particularly interested in students with background in neuroscience, physics,
mathematics, computer science, biology, or engineering.
The ability to approach research questions through a quantitative lens and experience in
programming are crucial for our team. While previous experience in neuroscience is not a
requirement, it is a strong plus.
We strongly encourage applications from individuals that have been traditionally
underrepresented in the sciences.

Opportunities

As a graduate student in our group, you will have the chance to contribute to exciting
discoveries, gain hands-on experience with state-of-the-art techniques, and work alongside experienced researchers.
Collaboration and mentorship are at the heart of our lab’s culture.
We believe that working together leads to better science and enriching experience. As a
graduate student in our lab, you will have the invaluable opportunity to work closely with
postdoctoral researchers who will help your research and foster your intellectual growth. By working together with your peers, you will have the chance to share ideas, problem-solve together, and gain fresh perspectives. Together, we will create an environment where you can thrive and achieve your full potential.
In addition, you will be enrolled in the Sorbonne graduate school and ICM student community, through which you will have access to a host of training opportunities and career development resources, as well as a range of social activities to ensure a well-rounded experience.

Why join our team

• We are a young and vibrant group of scientists, fueled by curiosity and passion for
understanding the brain.
• We work as a team and use or invent cutting-edge neurotechnologies to answer
fundamental questions in neuroscience.
• Our team is committed to the training, mentorship, and career development of the next
generation of neuroscientists. To achieve that, we foster an inclusive and supportive environment, where we can learn and advance science while having fun in the process.
• Our work is multi-disciplinary, and so is our team. Irrespective of your background and
project, our research environment will expose you to a diverse range of experimental
and computational aspects of systems and circuits neuroscience. We thus encourage everyone to apply, especially those from underrepresented minorities.
• Working in our team will provide you with invaluable experience across all stages of
research and you will have the opportunity to engage in experiment design and
execution, method development, software design, and data analysis, as well as
publishing and communicating research results.
• Our team is affiliated with Inserm and is located in the Paris Brain Institute (ICM),
where we have access to state-of-the-art facilities and resources.
• Our vibrant community at the ICM and throughout Paris promotes broad collaboration
and learning opportunities.

If you would like to know more, visit our website: neuronaldynamics.eu and read about our
team’s mission and values.

How to apply
If you are eager to join our vibrant research community and contribute to groundbreaking
discoveries, we warmly welcome your application.
Please send a statement of your past work and future research interests, your CV, and contact information for 1-3 references to the address: contact@neuronaldynamics.eu

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