Our science

To this day, 25 scientific teams work at the Paris Brain Institute with a shared goal:  improve neuroscience research and go further in the fight against neurological and psychiatric diseases.  The Paris Brain Institute's research teams are divided into 5 main fields: Cellular and molecular neurobiology, Integrative neurophysiology, Cognitive neuroscience, Clinical and translational Neuroscience, and Computational modelling in neuroscience. Those fields include a new research area that was created in 2021, which will focus on computational modelling.

To support our research teams projects, the Paris Brain Institute disposes core facilities and the latest technological equipment.
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Cellular and molecular neurobiology

The teams focused on this line of research aim at deciphering the influence of genetics, dissecting the molecular machinery, establishing the role of different types of cells and understanding the complex cellular interactions in normal or pathological conditions.

Integrative neurophysiology

The aim of the teams in this field is to better understand the physiology of neurons and their networks under normal and pathological conditions. The approaches shared by the Institute’s different teams include molecular, cellular, electrophysiological methods and optical recordings, optogenetics and the manipulation of neuronal activity through transcranial magnetic stimulation, as well as computer models that link physiological recordings amongst themselves.

Cognitive Neuroscience

The teams in this field combine structural, electrophysiological and functional studies to understand the functioning of neural networks on a whole brain scale as well as their importance in the onset of specific behaviors and cognitive processes in healthy individuals and in patients with neurological and psychiatric disorders.

Clinical and Translational Neuroscience

The aim of clinical and translational research is to enable the development of predictive or progression markers and treatments for neurological and psychiatric diseases, from identification in simple laboratory modelling to clinical trials at the Paris Brain Institute’s Clinical Investigation Center and throughout the entire Institute. Clinical and translational research increasingly involves computational neuroscience, the joint analysis of clinical and biological data, and therefore requires development of novel mathematical and statistical approaches, a field called Neuroinformatics.

Our new research area : Computational modelling in neuroscience

Until now, people using a computational neuroscience approach were included in the other research areas and applied their expertise in their host team. This new field will give them the opportunity to share their vision – complementary to that of the other fields – with the scientific and medical COPIL (steering committee) of the Institute.

The main objectives of the researchers in this new field are :

  • Mathematical and computational modeling of brain mechanisms at multiple scale
  • The development of data mining methods
  • The development of scientific software and engineering tools for neuroscience applications.

iCRINs : the clinical research facilities of the Paris Brain Institute

The aim of the iCRINs is to develop interactions and shared knowledge between the Neuroscience Department of the Pitié-Salpêtrière Hospital and the research teams of the Paris Brain Institute. The projects were evaluated by the Scientific Advisory Board of the Institut du Cerveau on the basis of expertise, performance, quality and visibility of the structure. 13 projects were selected and officially started in 2019, affiliated to the Clinical Investigation Center of the Paris Brain Institute.