Presentation
The 3 main aims are:
- To unravel the role of proneural proteins in generation and
diversification of neurons from neural progenitors; - To investigate the link between wiring variability and individualized innate behavior;
- To understand the normal physiological function of human
disease genes during brain development.
Major publications
- Linneweber GA, Andriatsilavo M, Dutta SB, et al.
A neurodevelopmental origin of behavioral individuality in the Drosophila visual system.
Science. 2020;367(6482):1112–1119. - 2. Ramaekers A, Claeys A, Kapun M, et al. Altering the Temporal Regulation
of One Transcription Factor Drives Evolutionary Trade-Offs between
Head Sensory Organs. Dev Cell. 2019. 50(6):780-92.e7 - Mora N, Oliva C, Fiers M, Ejsmont R, Soldano A, et al. A Temporal Transcriptional Switch Governs Stem Cell Division, Neuronal Numbers, and Maintenance of Differentiation. Dev Cell. 2018. 45(1):53-66.e5.
- Quan XJ, Yuan L, Tiberi L, Claeys A, De Geest N, et al. Post-translational Control of the Temporal Dynamics of Transcription Factor Activity Regulates Neurogenesis. Cell. 2016. 164(3):460-75.
- Langen M, Koch M, Yan J, De Geest N, Erfurth ML, et al. Mutual inhibition among postmitotic neurons regulates robustness of brain wiring in Drosophila. Elife. 2013. 2:e00337.
Contact
bassem.hassan@icm-institute.org
