From the drowsiness of a daydreaming commuter in his suburb train, to the heightened vigilance of a rock climber executing a difficult move, sensation during wakefulness takes place under drastically different conditions, themselves associated to various perceptual outcomes.
A remarkable property of sensory systems is therefore to provide a flexible strategy to process afferent information in a context-dependent manner. Such a flexibility in the computation of incoming signals appears to be a key feature of cortical processing in the healthy brain.
Indeed, reduced context-dependent sensory processing and adaptability underlies several brain disorders like Schizophrenia and Depression. Yet, the combination of circuit and cellular features shaping such modulations is still poorly understood.
In the lab we use a multidisciplinary approach, involving, electrophysiology, brain imaging (two-photon), optogenetics both in vivo and in vitro as well as computer modeling to understand how neuronal networks process sensory information and how this process is influenced by context. Working in the primary somatosensory cortex of mice we try to identify previously unnoticed cellular mechanisms that are essential for information
processing by the brain.
Our goal is also to investigate how such cellular mechanisms are modified or altered in the pathological brain and eventually uncover new molecular targets with potential therapeutical value.
- Rebola N, Reva M, Kirizs T, Szoboszlay M, Lorincz A, Moneron G, Nusser Z, DiGregorio DA, Distinct Nanoscale Calcium Channel and Synaptic Vesicle Topographies Contribute to the Diversity of Synaptic Function. Neuron 2019, (in press)
- Carta, M., Srikumar, S.N, Gorlewicz, A., Rebola, N* and Mulle C* Activity-dependent control of NMDA receptor subunit composition at hippocampal mossy fiber synapses. J. Physiol (*-Co-last authors)
- Rebola N, Carta M, Mulle C, Operation and plasticity of hippocampal CA3 circuits: implications for memory encoding. Nat, Rev. Neurosci. 2017 Apr;18(4):208-220.
- Vergnano AM*, Rebola N*, Savtchenko L*, Casado M, Kieffer B, Rusakov D, Mulle C and Paoletti P, Zinc dynamics and action at excitatory synapses, Neuron 2014, 82(5):1101-14. *-Co-first authors
- Carta M*, Lanore F*, Rebola N*, Szabo Z, Viana Da Silva S, Lourenço J, Verraes A, Nadler A, Schultz C, Blanchet C, Mulle, C. Membrane lipids tune synaptic transmission by direct modulation of presynaptic potassium channels, Neuron. 2014, 81(4):787-99. *-Co-first authors
- Rebola N, Carta M, Lanore F, Blanchet C, Mulle C. NMDA receptor-dependent metaplasticity at hippocampal mossy fiber synapses. Nature Neurosci. 2011Jun.;14(6):691–3.
- Rebola N, Luján R, Cunha RA, Mulle C. Adenosine A2A Receptors Are Essential for Long-Term Potentiation of NMDA-EPSCs at Hippocampal Mossy Fiber Synapses. Neuron. 2008 Jan.;57(1):121–34.
- Marvin JS, Scholl B, Wilson DE, Podgorski K, Kazemipour A, Müller JA, Schoch S, Quiroz FJU, Rebola N, Bao H, Little JP, Tkachuk AN, Cai E, Hantman AW, Wang SS, DePiero VJ, Borghuis BG, Chapman ER, Dietrich D, DiGregorio DA, Fitzpatrick D, Looger LL. Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR. Nat Methods. 2018 Nov;15(11):936-939