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Team “Basic to translational neurogenetics”


Physiopathology of neurological disorders Main domain : Cellular & molecular neurosciences Subdomain : Clinical & translational neurosciences

Alexandra DURR’s team focus on neurogenetic diseases, spinocerebellar degenerations – SCD (spastic paraplegias and cerebellar ataxias), frontotemporal lobar degenerations – FTLD and Huntington disease. These rare conditions share clinical, genetic and functional characteristics but are extremely heterogeneous both in molecular and clinical aspects.


Major publications

  • Coarelli G, Heinzmann A, Ewenczyk C, Fischer C, Chupin M, Monin ML, Hurmic H, Calvas F, Calvas P, Goizet C, Thobois S, Anheim M, Nguyen K, Devos D, Verny C, Ricigliano VAG, Mangin JF, Brice A, Tezenas du Montcel S, Durr A. Safety and efficacy of riluzole in spinocerebellar ataxia type 2 in France (ATRIL): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2022
  • Kacher R, Lejeune FX, Noel S, Cazeneuve C, Brice A, Humbert S, Durr A. Propensity for somatic expansion increases over the course of life in Huntington disease. Elife 2021
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Team members