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Alexis BRICE
MD, Professor of medical genetics, Sorbonne University-AP-HP
Team "Basic to translational neurogenetics"
Alexis BRICE
MD, Professor of medical genetics, Sorbonne University-AP-HP
Team "Basic to translational neurogenetics"
Biography
- 1995 – 2015 Head of the National Reference Center for “Neurogenetics”, Pitié-Salpêtrière Hospital, Paris (France)
- 2008 – 2012 Co-director of the Multi-body subject-specific Institute for Neurosciences, Cognitive Sciences, Neurology and Psychiatry, Aviesan (France)
- 2002 – 2009 Head of the Department of Genetics, Cytogenetics and Embryology, Pitié-Salpêtrière Hospital, Paris (France)
- 1992 – 2008 Coordinator of the group “Genetics of Neurodegenerative Disorders of the Central Nervous System”, in INSERM Unit 679 (former unit 289), Pitié-Salpêtrière Hospital, Paris (France)
- 1992 – 1995 Maître de Conférences (Assistant Professor) - Pierre et Marie Curie University (UFR Pierre and Marie Curie), Cell Biology, and Hospital practicioner, Pitié-Salpêtrière Hospital, Federation of Neurology (Prs Y. Agid and O. Lyon-Caen), Paris (France)
- 1988 – 1992 Hospital University Assistant in Cellular biology - Pierre et Marie Curie University, and Neurologist (Pitié-Salpêtrière Hospital, Department of Pr. F. Chain), Paris (France)
- 1985 – 1987 Research in molecular genetics, CNRS: Laboratory of Cellular and molecular neurobiology of Dr J. Mallet, Gif-sur-Yvette, France
- EDUCATION
- 2000 Certification (“Competence”) in Medical Genetics
- 1994 Authorization (“Habilitation”) to direct Researches, Pierre et Marie Curie University, Paris, (France)
- 1991 Board Certification in Neurology
- 1988 Doctor of Medicine (silver medal)
- 1987 - 1988 Residency in Neurology (Internat des Hôpitaux de Paris) at the Lariboisière and Pitié-Salpêtrière Hospitals
- 1986 M.S. (Biochemistry), Pierre et Marie Curie University, Paris (France)
- 1981 - 1984 Residency in Neurology at the Saint-Anne and Pitié-Salpêtrière Hospitals, Paris (France)
- 1974 - 1981 Medical Student (UFR Necker – Enfants Malades, René Descartes University, Paris (France)
Research work
Natural history, genetic basis and physiopathology of neurodegenerative diseases (Parkinson's disease, spinocerebellar degenerations)Publications
- LÜCKING, C.B., ABBAS, N., DÜRR, A., BONIFATI, V., BONNET, A-M., DE BROUCKER, T., DE MICHELE, G., WOOD, N.W., AGID, Y., BRICE, A., for The European Consortium on Genetic Susceptibility in Parkinson's Disease and The French Parkinson's Disease Genetics Study Group. - Homozygous deletions in parkin gene in European and North African families with autosomal recessive juvenile parkinsonism. Lancet, 352:1355-6, 1998. (IF : 60.39; citations: 151)
- LÜCKING, C.B., DÜRR, A., BONIFATI, V., VAUGHAN, J., DE MICHELE, G., GASSER, T., HARHANGI, B.S., MECO, G., DENEFLE, P., WOOD, N.W., AGID, Y., BRICE, A., and For the European Consortium on Genetic Susceptibility in Parkinson's Disease and the French Parkinson's Disease Genetics Study Group. – Association between early-onset Parkinson’s disease and mutations in the parkin gene. New Engl. J. Med. 342:1560-7, 2000. (IF: 74.699; citations: 1037)
- Groupe 1: IMBERT, G., SAUDOU, F., YVERT, G., DEVYS, D., TROTTIER, Y., GARNIER, J-M., WEBER, C., MANDEL, J-L.; Groupe 2: CANCEL, G., ABBAS, N., DÜRR, A., DIDIERJEAN, O., STEVANIN, G., AGID, Y., BRICE, A. - Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats and high instability. Nat. Genet., 14:285-91, 1996. (IF: 27.605; citations: 708)
- IBÁÑEZ, P., BONNET, A-M., DEBARGES, B., LOHMANN, E., TISON, F., POLLAK, P., AGID, Y., DÜRR, A., BRICE, A., and the French Parkinson’s Disease Genetics Study Group. - Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease. Lancet, 364(9440):1169-71, 2004. (IF: 60.39; citations: 729)
- DAVID, G., ABBAS, N., STEVANIN, G., DÜRR, A., YVERT, G., CANCEL, G., WEBER, C., IMBERT, G., SAUDOU, F., ANTONIOU, E., DRABKIN, H., GEMMILL, R., GIUNTI, P., BENOMAR, A., WOOD, N., RUBERG, M., AGID, Y., MANDEL, J-L., BRICE, A. - Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion. Nat. Genet., 17:65-70, 1997. (IF: 27.605; citations: 591)