Sandrine HUMBERT
Principal Investigator, PhD, DR1 INSERM
Team "Basic to translational neurogenetics"
Biography
Trained as a biotech engineer, S. Humbert worked during her PhD on transcription factors (JM Egly, IGBMC, Strasbourg). She then completed two post-doctoral stays (LH Tsai, Harvard Medical School, Boston and F Saudou, Institute Curie, Orsay) during which she focused on brain development and neurodegenerative processes. Since 2009, her team (at Institut Curie, Orsay and then Grenoble Institute Neuroscience, GIN) combines cellular approaches and analysis of mouse models to understand the physiological functions of huntingtin, the protein mutated in Huntington’s disease (HD), and to characterize the mechanisms underlying Huntington disease pathogenesis. She joined the ICM to lead a team with Pr A Durr for the next period contract (starting in January 2025).
Publications
In the last ten year, the major contribution of her team was to establish a connection between abnormal brain development and adult Huntington disease and to show that there is an early critical window of postnatal development that merits attention for future therapies.
ORCID 0000-0002-9501-2658