Presentation
The team has recently developed several in vitro and in vivo approaches and models in order:
- To investigate myelination processes in various species (mice, Xenopus, humans)
- To select new targets and validate new pharmacological compounds based on their complementary remyelinating models.
- To understand the molecular components and dynamics of glia-neuron interactions during remyelination
- To gain insight into inflammation, de/remyelination as well as energy dysregulation , with the goal to determine the influence of different components on neurodegeneration in MS patients
- To improve OPC tracers for in vivo labeling and to stratify patients for innovative clinical trials
Major publications
- Lubetzki C, Zalc B, Williams A, Stadelmann C, Stankoff B. Remyelination in multiple sclerosis: from basic science to clinical translation. Lancet Neurol. 2020 Aug;19(8):678-688
- Bodini B*, Poirion E*, Tonietto M, Benoit M, Palladino R, Maillart E, Portera E, Battaglini M, Bera G, Kuhnast B, Louapre C, Bottlaender M, Stankoff B. Individual mapping of innate immune cell activation is a candidate marker of patient-specific trajectories of disability worsening in Multiple Sclerosis. J Nuc Med, 2020;61(7):1043 1049
- Dubessy AL, Mazuir E, Rappeneau Q, Ou S, Abi Ghanem C, Piquand K, Aigrot MS, Thétiot M,Desmazières A, Chan E, Fitzgibbon M, Fleming M, Krauss R, Zalc B, Ranscht B, Lubetzki C, Sol-Foulon N. Role of a Contactin multi-molecular complex secreted by oligodendrocytes in nodal protein clustering in the CNS. Glia. 2019 Dec;67(12):2248 2263
- Bodini B., Veronese M., Garcia-Lorenzo D., Battaglini M., Poirion E., Chardain A., Freeman L., Louapre C., Tchikviladze, Papeix C., Dolle F., Zalc B., Lubetzki C., Bottlaender M., Turkeimer F., Stankoff B. Dynamic imaging of individual remyelination profiles in multiple sclerosis. Ann Neurol, 2016 Feb 18. (cited in the Jan 2017 issue of Lancet Neurology as one of the best 5 papers in MS in 2016).
- Freeman S.A., Desmazières A., Simonnet J., Gatta M., Pfeiffer F., Aigrot M.S., Rappeneau Q., Guerreiro S., Michel P.P., Yanagawa Y., Barbin G., Brophy P.J., Fricker D, Lubetzki C., Sol-Foulon N. Acceleration ofconduction velocity linked to clustering of nodal components precedes myelination. Proc Natl Acad Sci U SA 2015 Jan 20;112(3):E321-8.
6. Freeman L., Garcia-Lorenzo D., Bottin L., Leroy C., Louapre C., Bodini B., Papeix C., Assouad R., Granger B., Tourbah A., Dollé F., Lubetzki C., Bottlaender M., Stankoff B. The neuronal component of gray matter damage in multiple sclerosis: a PET study
Contact
catherine.lubetzki@icm-institute.org
bruno.stankoff@icm-institute.org
