Previous page Céline LOUAPRE Clinician, MD, PhD Team "Repair in Multiple Sclerosis: from biology to clinical translation "


  • 2009-2012 : Assistant Professor in Neurology, Sorbonne University, Pitié Salpêtrière Hospital
  • 2013-2015:  Research Fellow in Radiology, Harvard Medical School, MGH, Boston, MA
  • 2015 : Medical coordinator for clinical trials in multiple sclerosis, Neuroscience Clinical Investigation Center, ICM, Pitié-Salpêtrière Hospital
  • 2015 : Researcher at ICM in UMR_S 1127 Team "Repair in Multiple Sclerosis: from biology to clinical translation " C. Lubetzki, B. Stankoff
  • 2018 :  Associate Professor in Neurology, Sorbonne University, Pitié Salpêtrière Hospital
  • 2018 : Coordinator of the national clinical research network in multiple sclerosis FCRIN4MS
  • 2021 : Medical head of Neuroscience Clinical Investigation Center, Paris Brain Institute, Pitié-Salpêtrière Hospital

Research work

As a clinical neurologist holding a PhD in neuroscience, I am particularly interested on bringing novel technical developments in MR imaging to investigate multiple sclerosis (MS) pathophysiological mechanisms with a particular emphasis to cortical pathology, quantitative markers of demyelination/remyelination and neuroinflammation. Since 2015, I am medical coordinator of the Neuroscience Clinical Research Centre (CIC Neuroscience) at the Paris Brain Institute, conducting more than 80 clinical trials in the field of Neuroscience. Since 2018, I also coordinate together with Prof Gilles Edan (Rennes, FR) the national clinical research network for MS FCRIN4MS. In line with this experience in clinical research, my research work has been recently focused on developing translational clinical trials in remyelination strategies, and on developing multimodal approach to stratify cohorts of MS patients.

Since onset of COVID-19 pandemics, I initiated and coordinated the French registry COVISEP in order to characterize clinical outcomes and severity of COVID-19 in patients with MS.


• Clinical Characteristics and Outcomes in Patients With Coronavirus Disease 2019 and Multiple Sclerosis. Louapre C, Collongues N, Stankoff B, et al; Covisep investigators. JAMA Neurol. 2020 Jun 26:e202581

• Heterogeneous pathological processes account for thalamic degeneration in multiple sclerosis: Insights from 7 T imaging. Louapre C, Govindarajan ST, Giannì C, Madigan N, Sloane JA, Treaba CA, Herranz E, Kinkel RP, Mainero C. Mult Scler. 2018 Oct;24(11):1433-1444

• Beyond focal cortical lesions in MS: an in vivo quantitative and spatial imaging study at 7 T. Louapre C et al. Neurology. 2015 Nov 10;85(19):1702-9

• A gradient in cortical pathology in multiple sclerosis by in vivo quantitative 7 T imaging. Mainero C*, Louapre C*, Govindarajan ST, Giannì C, Nielsen AS, Cohen-Adad J, Sloane J, Kinkel RP. * contributed equally. Brain. 2015 Apr;138(Pt 4):932-45

• Brain networks disconnection in early MS cognitive deficits: an anatomo-functional study. Louapre C, Perlbarg V, Garcia-Lorenzo D, Urbanski M, Benali H, Assouad R, Galanaud D, Freeman L, Bodini B, Papeix C, Tourbah A, Lubetzki C, Lehericy S, Stankoff B. Human Brain Mapping, 2014 Sep;35(9):4706-17