Previous page Olga CORTI PhD, DR2, INSERM Team "Molecular Pathophysiology of Parkinson’s disease" https://institutducerveau-icm.org/fr/team/equipe-physiopathologie-moleculaire-parkinson/
BiographyOlga Corti obtained a BS in Biological Sciences at the University of Milan (1992) and was trained in molecular biology at the Carlo Besta Neurological Institute (S. Di-Donato’s lab, 1990-1993). She obtained a PhD degree in neurobiology at Pierre et Marie Curie University in Paris, after conducting research in the field of experimental gene therapy for Parkinson’s disease (J. Mallet’s lab, CNRS, 1994-1999; PhD thesis Award of the French Society for Neuroscience). After a post-doctorate devoted to the functional exploration of one of the first genes described to cause familial Parkinson’s disease forms (A. Brice’s lab, Inserm, 2000-2003), she was recruited as senior researcher at Inserm. She has a long-standing interest in PD pathomechanisms, with a focus on familial PD forms, and particularly PRKN-linked PD. Her research combines complementary approaches of biochemistry and molecular and cellular biology with mouse models and patient-derived cells, including iPSC-derived neurons, to investigate the impact of PD mutations on mitochondrial quality control and function, cellular vulnerability to stress and innate immunity.
Research workOlga Corti has a long-standing interest in PD pathomechanisms, with a focus on familial PD forms, and particularly PRKN-linked PD. Her research combines complementary approaches of biochemistry and molecular and cellular biology with mouse models and patient-derived cells, including iPSC-derived neurons, to investigate the impact of PD mutations on mitochondrial quality control and function, cellular vulnerability to stress and innate immunity.
1. Jacoupy M, Hamon-Keromen E, Ordureau A, Erpapazoglou Z, Coge F, Corvol JC, Nosjean O, Mannoury la Cour C, Millan MJ, Boutin JA, Harper JW, Brice A, Guedin D, Gautier CA, Corti O. The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells. Sci Rep. 2019 Aug 14;9(1):11829. doi: 10.1038/s41598-019-47352-9.
2. Bonello F, Hassoun SM, Mouton-Liger F, Shin YS, Muscat A, Tesson C, Lesage S, Beart PM, Brice A, Krupp J, Corvol JC, Corti O. LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson's disease. Hum Mol Genet. 2019 May 15;28(10):1645-1660. doi: 10.1093/hmg/ddz004.
3. Mouton-Liger F, Rosazza T, Sepulveda-Diaz J, Ieang A, Hassoun SM, Claire E, Mangone G, Brice A, Michel PP, Corvol JC, Corti O. Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20-dependent negative feedback loop. Glia. 2018; 66(8):1736-1751. doi: 10.1002/glia.23337.
4. Gautier CA, Erpapazoglou Z, Mouton-Liger F, Muriel MP, Cormier F, Bigou S, Duffaure S, Girard M, Foret B, Iannielli A, Broccoli V, Dalle C, Bohl D, Michel PP, Corvol JC, Brice A, Corti O. The endoplasmic reticulum-mitochondria interface is perturbed in PARK2 knockout mice and patients with PARK2 mutations. Hum Mol Genet. 2016;25(14):2972-2984. doi: 10.1093/hmg/ddw148.
5. Lesage S, Drouet V, Majounie E, Deramecourt V, Jacoupy M, Nicolas A, Cormier-Dequaire F, Hassoun SM, Pujol C, Ciura S, Erpapazoglou Z, Usenko T,Maurage CA, Sahbatou M, Liebau S,Ding J, Bilgic B, Emre M, Erginel-Unaltuna N, Guven G, Tison F, Tranchant C, Vidailhet V, Corvol JC, Krack P, Leutenegger AL, Nalls MA, Hernandez DJ, Heutink P, J. Gibbs JR, Hardy J, Wood NW, Gasser T, Durr A, Deleuze JF,Tazir M, Destée A, Lohmann E, Kabashi E, Singleton A, Corti O*, Brice A*.. Loss of VPS13C function in autosomal recessive parkinsonism causes mitochondrial dysfunction and increases PINK1/Parkin-dependent mitophagy. Am J Hum Genet 2016;98(3):500-13.