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Team “Frontal functions and pathology”

Presentation

Connectivity: frontal parietal,temporal and frontal-subcortical networks Main domain: Cognition Subdomain : Clinical & translational neurosciences The activities of the FRONTLAB team is a true collective research structured in 4 main tracks, all focused on the anatomical and functional organisation of the frontal lobes and associated networks for higher-order cognition in health and disease. The first track (human cognition) studies on how the human brain generates and valuates creative ideas. Computational modeling combined with cognitive tasks, neuroimaging, intraoperative recordings of brain activity in awake surgery and noninvasive brain stimulation are applied to investigate interaction between the processes of generating new ideas and those required to evaluate their appropriateness and originality. The second track (human behaviour), addresses how goal-directed behaviour is generated and what are the pathophysiological mechanisms underlying abnormally expressed goal directed behaviours, in particular, disinhibition and apathy). Our approach relies on classical approaches combined with the analysis of human behaviour in close to real-life situations using simulated scenarios in the lab or wired tracking devices at home. The third track (human brain organisation), investigates at the network level the causal structural and neurophysiological basis of cognitive functions and their impairments in healthy individuals and neurosurgical patients. It also addresses the characterization of activity states subtending the allocation, control and transient loss of sustained attention and its modulation with invasive and non-invasive brain stimulation technologies. The fourth track (“bench to bedside”) is a translational clinical program aiming to characterize genetic, molecular, neurophysiological and anatomical impairments leading to neuropsychiatric symptoms impacting frontal networks or explaining disease vulnerability. Multimodal approaches are applied to phenotype large cohorts of FTLD patients and on such basis contain their progression or reverse its symptoms with or molecular approaches or non-invasive brain stimulation (rTMS, tDCS, tACS).  

Major publications

Contact

richard.levy@icm-institute.org

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Team members

  • Antoni VALERO-CABRE

    Principal Investigator, MD, PhD, DR2, CNRS

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  • Benedicte BATRANCOURT

    Principal Investigator, PhD, IR, INSERM

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  • Bruno DUBOIS

    Principal Investigator, MD, PU-PH, Sorbonne University, AP-HP

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  • Emmanuel MANDONNET

    Principal Investigator, MD, PhD, PU-PH, University Paris X, AP-HP

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  • Emmanuelle VOLLE

    Principal Investigator, MD, PhD, CR1, INSERM

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  • Isabelle LE BER

    Principal Investigator, MD, PhD, PH, AP-HP

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  • Raffaella Lara MIGLIACCIO

    Principal Investigator, MD, PhD, CR1, INSERM

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