Team “Experimental neurosurgery”

Scientific Teams

Presentation

Basal ganglia, neurosurgery, movements disorders Main domain: Neurophysiology Subdomain: Clinical & translational neurosciences Brain LAU & Carine KARACHI’s team aims to characterize the subcortico-cortical anatomy and physiology of brainnetworks involved in motor control, with the long-term goal of developing new therapies including novel applications of deep brain stimulation (DBS).

The team’s future research is focused on:
– Anatomo-functional comprehension of networks involving DBS targets;
– Comprehension of these targets using behavioral tasks coupled with electrophysiology;
– Development of new therapies such as understanding how neurofeedback can be used to ameliorate movement disorders in Parkinson’s disease.

Major Publications

Lau B., Meier N., Serra G., Czernecki V., Schuepbach M., Navarro S., Cornu P., Grabli D., Agid Y., Vidailhet M., Karachi C., Welter M.-L. (2019): Axial symptoms predict mortality in patients with Parkinson disease and subthalamic stimulation. Neurology. 92: 2559-2570.
Karachi C., Cormier-Dequaire F., Grabli D., Lau B., Belaid H., Navarro S., Vidailhet M., Bardinet E., Fernandez-Vidal S., Welter M.-L. (2019): Clinical and anatomical predictors for freezing of gait and falls after subthalamic deep brain stimulation in Parkinson’s disease patients. Parkinsonism & Related Disorders. 62: 91-97.
Sébille S.*, Rolland A.-S.*, Faillot M., Perez-Garcia F., Colomb-Clerc A., Lau B., Dumas S., Fernandez Vidal S., Welter M.-L., Francois C., Bardinet E., Karachi C. (2019): Normal and pathological neuronal distribution of the human mesencephalic locomotor region. Movement Disorders. 34: 218-227.
Welter M.-L., Houeto J.L., Thobois S., Bataille B., Guenot M., Worbe Y., Hartmann A., Czernecki V., Bardinet E., Yelnik J., Tezenas du Montcel S., Agid Y., Vidailhet M., Cornu P., Tanguy A., Ansquer S., Jaafari N., Poulet E., Serra G., Burbaud P., Cuny E., Aouizerate B., Pollak P., Chabardes S., Polosan M., Borg M., Fontaine D., Giordana B., Raoul S., Rouaud T., Sauvaget A., Jalenques I., Karachi C., Mallet L., for the STIC study group. (2017): Anterior pallidal deep brain stimulation for Tourette’s syndrome: a
double-blind randomized parallel controlled trial. Lancet Neurology. 16:610-619.
Sébille S.*, Belaid H.*, Philippe A., André A., Lau B., François F., Karachi C., Bardinet E. (2016): Anatomical evidence for functional diversity in the mesencephalic locomotor region of primates. NeuroImage. 147: 66-78.
Lau B., Welter M.-L., Belaid H., Fernandez Vidal S., Bardinet E., Grabli D., Karachi C. (2015): The integrative role of the pedunculopontine nucleus in human gait. Brain. 138: 1284–1296.