Scientific Teams

Previous page

Team “Experimental therapeutics of Parkinson’s disease”


Physiopathology of neurogical disorders Main domain: Cellular & molecular neuroscience

Etienne Hirsch & Stéphane Hunot’s team aims to understand the mechanisms underlying disease progression in Parkinson Disease (PD) and to identify and validate new disease-modifying treatments. Besides intrinsic neuronal mechanisms and transneuronal propagation of the proteinopathy, the team posits that disease progression also relies on a complex pathological cell-cell interaction network.

The specific aims of the team are to better describe:

  • How pathological protein assemblies (α-Syn and Tau) and other inflammatory cues shape microglial cell responses?
  • How disease-associated brain vascular changes modulate neuroinflammation and clearance of pathological protein assemblies?
  • How progressive dysfunction of non-DA neurotransmitter (NT) systems impacts on neurodegeneration and on immune cell polarization and function?
  • How disease-relevant environmental factors impact PD pathogenesis?

Major publications

1. Dos-Santos-Pereira M, Guimarães FS, Del-Bel E, Raisman-Vozari R, Michel PP. Cannabidiol prevents LPS-induced microglial inflammation by inhibiting ROS/NF- B-dependent signaling and glucose consumption. Glia. 2020 68(3):561-573.

2. Parillaud VR, Lornet G, Monnet Y, Privat AL, Haddad AT, Brochard V, Bekaert A, de Chanville CB, Hirsch EC, Combadière C, Hunot S, Lobsiger CS. Analysis of monocyte infiltration in MPTP mice reveals that microglial CX3CR1 protects against neurotoxic over induction of monocyte-attracting CCL2 by astrocytes. J Neuroinflammation. 2017 21;14(1):60.

3. Laurent C, Dorothée G, Hunot S, Martin E, Monnet Y, Duchamp M, Dong Y, Légeron FP, Leboucher A, Burnouf S, Faivre E, Carvalho K, Caillierez R, Zommer N, Demeyer D, Jouy N, Sazdovitch V, Schraen-Maschke S, Delarasse C, Buée L, Blum D. Hippocampal T cell infiltration promotesneuroinflammation and cognitive decline in a mouse model of tauopathy. Brain. 2017 140(1):184-200.

4. Mécharles S., Herrmann C., Poullain P., Tran T.H., Deschamps N., Mathon G., Landais A., Breurec S., Lannuzel A. Acute myelitis due to Zika virus infection. Lancet. 2016 2; 387(10026):1481.

5. Michel P.P., Hirsch E.C., Hunot S. Understanding Dopaminergic Cell Death
Pathways in Parkinson Disease. Neuron. 2016 18; 90:675-91.

More information Hide

Team members

  • Annie LANNUZEL

    Principal Investigator, MD, PhD PU-PH, Sorbonne University, AP-HP

    More information
  • Patrick MICHEL

    Principal Investigator, PhD, Cadre EPIC

    More information

    Porteur de projet, PhD, DR2 emeritus, CNRS

    More information