Presentation
The central goal of our team is to establish mechanistic-causal links between single neuron properties and large-scale brain dynamics, an approach requires to elucidate the different facets of the pathophysiology of focal to generalized epilepsies. In complement of this research, the team explores extreme brain conditions with abnormal and sustained electrical activities (from isoelectric status to status epilepticus, up to near-death states).
Major publications
- Schramm AE, Carton-Leclercq A, Diallo S, Navarro V, Chavez M, Mahon S, Charpier S (2020). Identifying neuronal correlates of dying and resuscitation in a model of reversible brain anoxia. Prog Neurobiol. 185:101733.
- Lambrecq V., Lehongre K., Adam C., Frazzini V., Mathon B., Clemenceau S., Hasboun D., Charpier S., Baulac M., Navarro V., Le Van Quyen M. (2017) Single-unit activities during the transition to seizures in deep mesial structures. Ann Neurol.;82(6):1022 1028.
- Williams M., Altwegg-Boussac T., Chavez M., Lecas S., Mahon S. and Charpier S. (2016). Integrative properties and transfer function of cortical neurons initiating absence seizures in a rat genetic model. J Physiol. (London) 594: 6733-6751. This article was featured at the journal’s perspectives: Polack, P.O. (2016). J Physiol. (London) 594:6439-6751, 2016.
- Navarro V., Dagron C., Elie C., Lamhaut L., Demeret S., Urien S., An K., Bolgert F., Tréluyer J.M., Baulac M., Carli P. (2016) Levetiracetam and clonazepam in status epilepticus: A prehospital doubleblind randomised trial. Lancet Neurology 15: 47-55.
- Lopez-Persem A, Bastin J, Petton M, Abitbol R, Lehongre K, Adam C, Navarro V, Rheims S, Kahane P, Domenech P, Pessiglione (2020). Four core properties of the human brain valuation system demonstrated in intracranial signals. Nat Neurosci. 23(5): 664-675.