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Team “Dynamics of Epileptic Networks and Neuronal Excitability”


Dynamics and physiopathology of neural networks, epilepsy
Main domain: Neurophysiology
Subdomain : Clinical & translational neurosciences

Stéphane CHARPIER, Mario CHAVEZ & Vincent NAVARRO ’s team investigates how the brain can become epileptic (epileptogenesis), how it produces seizures (ictogenesis), and the relationship between neurophysiological activities and clinical semiology. In addition, the team investigates extreme brain conditions with abnormal and sustained electrical activities (isoelectric status and status epilepticus).


The team has a unique multi-scale, translational approach. The research includes in vivo recordings from both human epileptic patients as well as animal models of spontaneous seizures, from the cortex to the basal ganglia. The goal is to establish mechanistic links between single neuron properties and large-scale brain dynamics, and elucidate the different facets of the pathophysiology of focal to generalized epilepsies.



Major publications

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Team members

  • Severine MAHON

    Principal Investigator, PhD, CR1, INSERM

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  • Virginie LAMBRECQ

    Principal Investigator, MD, PhD, MCU-PH, Sorbonne university, AP-HP

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