POSITION
The Paris Brain Institute (Institut du Cerveau) is recruiting a Clinical trial Assistant for its industrial clinical research unit « Neurotrials » and its academic clinical research support unit « Cellule Support RIPH ».
Within the Institute, the Neurotrials unit is a CRO-type early-stage clinical research unit for the design, management and conduct of phase Ib/IIa clinical trials, with industrial sponsorship, in drug development or in the field of medical devices. In addition to its Neurotrials unit, the Institute has also created a unit dedicated to supporting research involving human subjects (RIPH) for institutional (ICM) sponsorship as part of its contribution to clinical research.
MAIN JOB DUTIES
• General office organization, including reception coverage, ordering supplies, shipping, managing inventory, etc.;
• Perform administrative duties in conformity with internal policies and procedures;
• Provide day-to-day project support activities – maintenance of project-related files, such as maintenance of TMF, document naming and versioning, creation of hyperlinks;
• Assist the team with the preparation, formatting, handling, distribution, and filing of clinical documentation and reports according to the scope of work and standard operating procedures
• Coordinate internal and with sponsor/partner meetings, attend relevant clinical study meetings as deemed appropriate and provide meeting minutes.
• Set up and organize events, schedule appointments, make travel arrangements for staff/ visitors;
• Maintain databases/spreadsheets as necessary to facilitate tracking/documentation of the Neurotrials unit activities;
• Arrange the signing process of documents in conjunction with relevant departments within the Institute and/or partners or clients;
• Coordination of PR communication activities;
• Perform other administrative tasks as needed.
PROFILE
• A high school diploma (bachelor’s degree preferred); Fluent (Proficiency) both in French and English;
• At least 1 year of assistant experience (CTA experience preferred);
• Excellent organizational and prioritization skills;
• Time management and multitasks abilities;
• Proficiency in Microsoft Office Package;
• Attention to detail and excellent oral and written communication skills.
• Excellent social and teamwork skills
Apply to: recrutement@icm-institute.org indicating « Clinical Trial Assistant »
The Paris Brain Institute is a private foundation recognized as being of public utility, whose purpose is fundamental and clinical research on the nervous system. On the same site, 700 researchers, engineers and doctors cover all the disciplines of neurology, with the aim of accelerating discoveries on the functioning of the brain and the development of treatments for diseases such as: Alzheimer’s, Parkinson’s, multiple sclerosis, epilepsy, depression, paraplegia, tetraplegia, etc.
POSITION
Context
Data Analysis Core facility (DAC) serves as a central hub for research data analysis and data management at the Paris Brain Institute, consisting of an enthusiastic team of experts in omics analysis, image analysis, machine learning, statistical methodology, and data management.
Job description
We are looking for people to support the implementation of the institute’s strategy to collect, process and publish data “as open as possible, as closed as necessary”. As the Open Science Officer, you will provide in-person support and be responsible for developing the documentation and guidelines to address the diversity of data collected at the institute. You will champion the institute’s strategy within national and international networks and ensure that the institute becomes a reference for practical, evidence-based data governance in neuroscience. In short, you will:
- Serve as the primary contact for researchers and support staff for FAIR data practices from collection to reuse, providing guidelines, documentation, and hands-on assistance for Data Management Plans.
- Educate and engage the local research community through workshops, training, and symposia.
- In close collaboration with the Chief Data Officer, provide specification and conduct usability testing for the development of data management solutions by the IT development team.
- Foster collaboration between research teams, CDO, IT department, RSSI, legal office, DPO, risk assurance, scientific integrity officer, and RIPH support.
- Participate in national and global initiatives in data management and open science, including INBS, IFB, French Reproducibility Network, and RDA.
- Engage in data management collaborations with national and international research institutions to align best practices and facilitate compliant data sharing.
- Address data governance issues with all stakeholders.
- Communicate and champion the institute’s open science strategy and accomplishments in collaboration with the scientific and medical affairs department, communication department, and institute leadership.
PROFILE
Know-how
- Experience in a research environment (academic or industry)
- Experience in implementing and advocating for data governance and open science for different stakeholders, including scientists, students, engineers, managers, and policy makers.
- Experience in creating educational resources, organizing training, workshops, and conferences.
- Experience in data protection regulations (GDPR), French health law, data protection assessments and regulatory ethical procedures (e.g., CNIL, APAFIS, CODECOH)
Knowledge
- PhD in (cognitive) neuroscience, biology or related field
- Broad understanding of best practices in data management across several data modalities in human and/or animal research, such as neuroimaging, microscopy, electrophysiology, cognitive tests, clinical research trial protocols, biological samples and sample preparations or sequencing data
- Understanding of digital solutions (software and tooling) for data management and (clinical) research databases (e.g., REDCap, LIMS, ELNs, OMERO, XNAT) desired but not required.
- Academic level in English (required) and conversational French (desired)
Soft skills
- Proven affinity for FAIR, open science practices, and personal data protection
- Proven organizational and project management skills.
- Proven ability to communicate with different stakeholders, respecting different background, needs, timetables, and expertise.
- Proven affinity animating and coordinating (inter)national networks in open science, data management or scientific reproducibility.
- Flexible, solution-oriented, with autonomy and initiative, and a hands-on attitude
- Excellent interpersonal skills
Conditions
- Starting date: as soon as possible
- Contract duration : permanent position (CDI).
- Remuneration: according to the level of study and experience.
- Location: Paris Brain Institute, Hôpital Pitié-Salpêtrière, 75013 PARIS.
Please send your resume and motivation letter (in English), indicating name and contact details of two references (incomplete applications will not be considered) to recrutement@icm-institute.org and stephen.whitmarsh@icm-institute.org with the subject: “Open Science Officer”
POSITION
Context
The Data Analysis Core facility (DAC) is a core facility of the Paris Brain Institute that supports researchers in the discovery of new insights and treatments in the field of neurological diseases and disorders. The DAC consists of an enthusiastic interdisciplinary team of experts in biostatistics, bioinformatics, image analysis, and data managers. We accompany researchers throughout the research cycle, by providing robust and reproducible analyses, expert advice, training, and the development of new solutions for emerging technologies. If you are interested in the brain and want to contribute to discoveries in a stimulating research environment, the DAC could be the place for you.
Missions
We are looking for senior bioinformatician to reinforce our ability to tackle the questions of today. The fast-evolving field requires initiative to find solutions, and a sensitivity to quality control, communication with research teams, and teamwork. Technical expertise and experience in several omics modalities are needed to meet the increasingly complex and multimodal bioinformatics approaches. As a member of our omics analysis team, you will be responsible for the translation of biological questions into actionable insights through bioinformatics analyses. You will be expected to be independent in managing multiple projects simultaneously, ensuring quality through regular rapports and communication with research teams under the supervision of our omics team manager and supported by the team’s project manager.
- Provide support to research teams in the analysis and interpretation of (multi)omics data, including (but not limited to) scRNAseq and Spatial Transcriptomics.
- Participate in developments of bioinformatics pipelines and workflows for (multi)omics data analysis, ensuring accuracy, reproducibility, and scalability.
- Collaborate with computational biologists, geneticists, and clinicians to integrate (multi)omics data and facilitate translational research efforts.
- Stay updated with the latest advancements in omics technologies, bioinformatics tools, and analytical methods, and contribute to the continuous improvement of data analysis workflows.
PROFILE
Know-how
- Expertise in the analysis of several omics data types, e.g. spatial transcriptomics, single-cell and/or bulk RNA sequencing, single-cell and/or bulk ATAC sequencing, proteomics, WGS/WES sequencing, methylation data, CHIPseq.
- Experience in complex experimental designs, e.g. non-custom references, multi-omics data integration, and integration of multiple variables in bulk designs.
- Proficiency in UNIX environments (shell).
- Proficiency in R (required), and Python (desired), in a version-controlled setting (Git).
- Proficiency in data visualization.
- Professional experience of at least four years in the field of omics analysis in academia or industry.
- Proven experience in routine and complex omics analyses.
- Proven experience in communicating and interpreting results for researchers/biologists.
- Academic reading, writing, and conversational skills in English (required) and French (desired).
Knowledge
- Minimum Bac+5 (master or engineer) in bioinformatics, or equivalent level in biology/computing.
- Training in omics analyses, including but not limited to, batch effect correction, differential expression, pathways enrichment, trajectory analyses, and deconvolution.
Soft skills
- Ability to work in a team according to common procedures.
- Autonomy, initiative, and flexibility in finding solutions for new and unexpected issues.
- Ability to communicate with people from various scientific and technical backgrounds.
- Motivation to advance research in neuroscience!
Conditions
- Remuneration: according to the level of study and experience.
Please send your CV and letter of motivation (in English), indicating name and contact details of two references (incomplete dossiers will not be considered) to recrutement@icm-institute.org and marie.coutelier@icm-institute.org with the subject: “Senior bioinformatician (M/F)”.
POSITION
Context
The Paris Brain Institute engages increasingly in large multi-cohort, multi-central transversal clinical research studies that aim to allow integrated data exploration and prediction models across diverse sets of retrospective and prospective clinical research databases, integrating multimodal data from neuroimaging, biological samples, and omics. These studies require long-term solutions that ensure interoperability across the diversity of research data. The Data Analysis Core facility (DAC) supports researchers throughout this process by providing robust and reproducible analysis and data management solutions. If you are interested in data, biology and neuroscience and want to contribute to discoveries in a stimulating research environment, the DAC could be the place for you.
Missions
We are currently looking for data managers to help us manage a diversity of clinical data collected and analyzed at the institute, as part of multimodal studies that integrate neuroimaging, microscopy, electrophysiology, behavior data and biological samples. You will be responsible for designing electronic data capture within REDCap in close collaboration with research teams, data acquisition platforms, project managers and engineers, under the supervision and – supported by – our clinical research data manager. You will be part of ambitious programs aimed at discovering new insights and treatments for neurological diseases and neurodegenerative disorders, by reinforcing Good Clinical Practices in data science within a transversal team that includes IT, Legal office, Data Protection Officer, support for human studies (RIPH), and risk assurance. Your tasks will include:
- Using REDCap to design eCRFs.
- Design and perform quality control of large cohort clinical research databases using built-in solutions and where needed develop your own.
- Administrate and perform maintenance on REDCap databases.
- Implement solutions to ensure consistency of REDCap databases with multi-modal data, including neuroimaging and multi(omics).
- Implement harmonization and interoperability across (retrospective) clinical research databases.
- Optimize user-interfaces in REDCap.
- Document processes, including guidelines for clinical research data management.
PROFILE
Know-how
- Hands-on experience in the use and configuration of REDCap or other eCRF systems (highly desired)
- Experience in Good Clinical Practices (GCP), i.e. Bonnes Pratiques Cliniques (BPC)
- Programming experience in markup languages desired, especially in HTML
- Professional experience in a research environment (academic or industry)
- Understanding digital tools for data management and (clinical) research databases (e.g., REDCap, CDISC)
- Understanding of clinical research ontologies (e.g. BioPortal, FHIR)
- English and/or French language skills
Knowledge
- Master’s degree or higher in data management, bioinformatics, biotechnology, or related field
Soft skills
- Autonomy and initiative, with a hands-on attitude
- Excellent organizational and project management skills
- Flexible and solution-oriented with the ability to communicate with researchers and staff from different backgrounds and with different needs, timetables, and understanding.
Conditions
- Remuneration: according to the level of study and experience
Please send your CV and letter of motivation (in English), indicating name and contact details of two references (incomplete dossiers will not be considered) to recrutement@icm-institute.org and stephen.whitmarsh@icm-institute.org with the subject: “Clinical Research Data Manager M/F”.
