member

Previous page Severine BOILLEE PhD, CR1, INSERM Team "ALS : causes and mechanisms of motor neuron degeneration" https://institutducerveau-icm.org/en/team/team-boillee/ https://www.facebook.com/people/Icm-Team-Boillee/100005216566353/

Biography

Séverine Boillée is the head of the “ALS causes and mechanisms of motor neuron degeneration” team at Paris Brain Institute and is an associate professor at INSERM. She received her PhD in Neurosciences in 2001 at the University Paris XII and specialized on ALS through her post-doc at UCSD with Pr. Don W Cleveland. In 2011, she received, together with the Pr. Vincent Meininger the “NRJ-Institut de France” prize for her research on ALS. She is a scientific board member of the Thierry Latran Foundation (European ALS association), the ARSLA (French ALS association) and of the steering committee of the Medical Rare Disease ALS branch (FILSLAN).

Research work

Intérêts : Amyotrophic ateral Sclerosis (ALS), motor neuron, neurodegeneration, neuroinflammation, microglia/macrophage

Séverine BOILLEE’s team investigates mechanisms of motor neuron (MN) degeneration in Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig’s disease or Charcot’s disease) resulting from pathological interactions between MNs and microglia/macrophages to find therapeutically promising pathways to slow disease progression. Séverine BOILLEE’s projects are more specifically focused on:

• Understanding how peripheral macrophages influence MN survival and ALS disease progression in ALS

• Finding how macrophages from ALS patients differ from control macrophages to find new pathways implicated in disease progression

Publications

  • Ribon M, Leone C, Chiot A, Berriat F, Rampanana M, Cottin J, Bohl D, Millecamps S, Lobsiger CS, Heneka MT, Boillée S. Deletion of the inflammatory S100-A9/MRP14 protein does not influence survival in hSOD1G93A ALS mice. Neurobiol Aging. 2021 May;101:181-186. PMID: 33626479
  • Chiot A, Zaïdi S, Iltis C, Ribon M, Berriat F, Schiaffino L, Jolly A, de la Grange P, Mallat M, Bohl D, Millecamps S, Seilhean D, Lobsiger CS, Boillée S. Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival. Nat Neurosci. 2020 Nov;23(11):1339-1351. PMID: 33077946
  • Mesci P, Zaïdi S, Lobsiger CS, Millecamps S, Escartin C, Seilhean D, Sato H, Mallat M, Boillée S.  System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice. Brain. 2015 Jan;138(Pt 1):53-68. PMID: 25384799
  • Lobsiger CS*, Boillée S*, Pozniak C, Khan AM, McAlonis-Downes M, Lewcock JW, Cleveland DW.  C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):E4385-92. PMID: 24170856 (* equal contribution)
  • Boillée S*, Yamanaka K*, Lobsiger CS, Copeland NG, Jenkins NA, Kassiotis G, Kollias G, Cleveland DW.Onset and progression in inherited ALS determined by motor neurons and microglia. Science. 2006 Jun 2;312(5778):1389-92. PMID: 16741123 (* equal contribution)