Previous page Eric LEGUERN MD, PhD, PU-PH, Sorbonne Université/APHP Team "Genetics and physiopathology of epilepsy" []


Eric Leguern is co-leader of the team entitled “Genetics and physiology of epilepsy” at the ICM. He received a MD in 1990, and a PhD in 1991 (Paris V University). He is professor of Medical genetics and hospital pratician in the department of genetics of the Pitié-Salpêtrière Hospital. He is head of the neurogenetics laboratory. He is also member of scientific committees or societies, including the European Academy of Sciences, the American Association of Neurology, the French Society of Neurology and the National Assembly of Hospital Molecular Geneticists.

Research work

Genetic generalized epilepsies. Eric LEGUERN investigates epileptic encephalopathies and genetic generalized epilepsies:
  • To characterize pathophysiological mechanisms of HCN1-epileptic encephalopathy, identify new genetic causes of fever-sensitive epileptic encephalopathies, and search for factors modulating the severity of the phenotype.
  • To explore how mutations found by the team in several presynaptic proteins lead to genetic generalized epilepsies (GGE).


Nava C, Dalle C, Rastetter A, Striano P, de Kovel CG, Nabbout R, Cancès C, Ville D, Brilstra EH, Gobbi G, Raffo E, Bouteiller D, Marie Y, Trouillard O, Robbiano A, Keren B, Agher D, Roze E, Lesage S, Nicolas A, Brice A, Baulac M, Vogt C, El Hajj N, Schneider E, Suls A, Weckhuysen S, Gormley P, Lehesjoki AE, De Jonghe P, Helbig I, Baulac S, Zara F, Koeleman BP; EuroEPINOMICS RES Consortium, Haaf T, LeGuern E, Depienne C (2014). De novo mutations in HCN1 cause early infantile epileptic encephalopathy. Nat Genet. Jun;46(6):640-5.