Research Published December 29 2016
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The publication of Benedetta Bodini and Bruno Stankoff, researchers at the Institut du Cerveau – ICM, on the use of a new imaging technique in multiple sclerosis, was selected by Lancet Neurology among the top 5 of 2016 to improve the understanding and knowledge of this disease.

The article “Dynamic Imaging of Individual Remyelination Profiles in Multiple Sclerosis” was just recognized by Lancet Neurology as one of the top 5 publications of the year 2016 that have “improved understanding, or raised awareness on multiple sclerosis “. The journal Lancet Neurology is one of the leading journals in the field of neuroscience.

Institut du Cerveau – ICM researchers have developed a new imaging method to visualize neurons demyelination and remyelination, and quantify their degeneration.

The Lancet Neurology stated that “The use of pathology-specific imaging biomarkers is an innovative strategy to improve the understanding of underlying mechanisms in multiple sclerosis. Although MRI is particularly useful for diagnosis and clinical trials, PET (Positron Emission Tomography) extends the field of observation, as it was magnificently shown by a study of Bodini et al. on demyelination and remyelination. This study, carried out on 20 patients, has helped to develop a remyelination index that reflects the individual repair potential and that is inversely associated with the progression of the disability. “.


“I am very flattered that this publication was selected as one of the top five of the year by The Lancet Neurology; this strengthens and encourages us in our research. Using this technique, we will eventually be able to stratify patients according to their potential for spontaneous remyelination in order to adapt the treatment for the best. It is also useful to evaluate remyelinating drugs in clinical trials.”– B. Bodini.


Reference : Dynamic imaging of individual remyelination profiles in multiple sclerosis. Bodini B, Veronese M, García-Lorenzo D, Battaglini M, Poirion E, Chardain A, Freeman L, Louapre C, Tchikviladze M, Papeix C, Dollé F, Zalc B, Lubetzki C, Bottlaender M, Turkheimer F, Stankoff B. Ann Neurol. 2016 Feb 18.