PHENO-ICMice : rodent preclinical phenotyping service

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The Rodent Service is a 1500 sqm facility in Paris dedicated to research on new rodent models of human diseases and their use in preclinical studies. The facility supplies state of the art equipment and specialized staff to academics and industrials. With 7000 ventilated cages, both SOPF and SPF housing areas are provided, including ABSL1 and ABSL2 and 40 equipped procedure rooms. A well-established outsource company is in charge of animal care. PHENO-Institut du Cerveau – ICMice is part of the Institut du Cerveau – ICM core facility network (small animal MRI, sequencing, vectorology, histology, microscopy…) which facilitates translational research.


Three activities are offered to support research projects at any step for all services

• Rodent behavioral department (mice and rat)
• Rodent surgery departement (mice and rat)
• Rodent lines preservation departement (mice)


Service delivery : the team provides advice about design of experimental projects or protocols, adequate selection and use of specific behavioral tests or sugery experiment, data analyses and manuscript writing

Staff training: the team also proposes specialized training sessions for the use of specific equipment and software

Room/Equipment rental: 12 procedure rooms including more than 20 behavioral tests, 10 surgery boxes are available for rent


Basic motor and sensory function: homecage scan, seizure scan, rotarod, locotronic, open field, actimeter, running wheel, Y maze, runway, treadmill, hot/cold plate, SHIRPA

• Learning and memory: Morris water maze, radial arm maze, fearconditioning, empathy chamber, object recognition
• Social behavior: group scan, sociability chamber
• Anxiety and depression-like behaviors: elevated plus maze, dark/lightchamber, tail suspension, forced swim
• Attention: 5-9 holes
 • USV : ultravocalization

• Muscular strength: Grip strength meter, grid


Stereotactic surgery (brain and spinal cord

• Live imaging (bi-photon)
• Microdialysis (CSF)
• Electroporation (pups)
• Tissue harvest (all or target structure of brain & spinal cord, peripherical organs)


• Embryo transfert
• Cryopreservation


• Housing capacity: 3000 cages SPF and 4000 cages SOPF
• Ventilated cages system
• Biosafety level : ABSL 1 & ABSL 2
• Automated cage wash system

• Restricted access


• Breeding
• Plugging
• Weaning
• Tissue harvest-genotyping
• Tattooing
• Cleaning-feeding


Actively involved in ethical respect of 3R rules