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E-PHYS is an unique core facility providing high quality contract research services to academics and pharmaceutical industry requiring in vitro, ex vivo and in vivo electrophysiology technique for successful completion of neurosciences studies. The facility is equipped for patch-clamp, multielectrode array (MEA), electromyography (EMG) and electroencephalography (EEG) recordings. The facility is involved in many different research projects as diverse as the studies of channelopathies, human iPSC derived neurons and neuronal plasticity. ePHYS is part of the Institut du Cerveau – ICM core facility network (sequencing, vectorology, cell culture, iPSC…) which facilitates translational research projects. This activity is supported by the IHU-A-Institut du Cerveau – ICM funding.


  • Generation of full set of data by expert staff (experimental design, data acquisition, analysis and interpretation)
  • Access to the equipment for independent use• Preliminary experiments designed to assess project feasibility
  • Consulting
  • Training  in electrophysiology techniques
  • Development of new assays on request


  • Patch-clamp rig equipped with an inverted microscope for patch-clamp recordings from cell culture
  • Patch-clamp rig equipped with an upright microscope, for patch- clamp recordings from brain slice and zebrafish, including optogenetic stimulationMultielectrode Array (MEA) system for multiple recordings of extracellular field potential
    from brain slices and 2D/3D cell culture(field evoked postynaptic potential (fPSP) and spike)
  • EMG/PE Recording System to investigate the sensory and motor system in rodent
  • Long-term video ElectroEncephaloGraphy (EEG) recording with synchronized video in rodent
  • Fast pressurized system for recording of ligand-gated ion channels and fast drug application


Nelson REBOLA —Scientific manager
Carine DALLE —Operational manager & Research engineer
Charlotte DELEUZE —Research engineer

Delphine ROUSSEL – Research engineer