Presentation
Major publications
- Piguet F., Alves S., Cartier N. Clinical Gene Therapy for Neurodegenerative diseases : Past, present and Future. Human gene therapy, oct 2017.
- Piguet F., de Montigny C., Vaucamps N., Reutenauer L., Eisenmann A., Puccio H. Rapid and complete reversal of sensory ataxia by gene therapy using a novel mouse model of Friedreich ataxia. Molecular Therapy, June 2018.
- Orefice, N.S, Souchet B., Breaudeau J., Alves S., Piguet F., Collaud F., Ronzitti G., Tada S., Hantraye P., Mingozzi F., Ducongé F., Cartier N. Real-Time Monitoring of Exosome Enveloped-AAV Spreading by Endomicroscopy Approach: A New Tool for Gene Delivery in the Brain. Methods & Clinical Development Volume 14, P237-251, September 2019.
- The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease.
- Nóbrega C, Conceição A, Costa RG, Koppenol R, Sequeira RL, Nunes R, Carmo-Silva S, Marcelo A, Matos CA, Betuing S, Caboche J, Cartier N, Alves S. BMC Res Notes. 2020 Apr 10;13(1):210. doi: 10.1186/s13104-020-05053-x. PMID: 32276655
- Piguet F., de Saint Denis T., Audouard E.; Beccaria K., André A., Wurtz G., Schatz R., Alves S., Sevin C., Zerah M and Cartier N. The challenge of gene therapy for neurological diseases: strategies and tools to achieve efficient delivery to the central nervous system. Human Gene Therapy. In Press 2020.
- Audouard E., Rousselot L., Folcher M., Cartier N. and Piguet F. Optimized protocol for sub-cutaneous implantation of encapsulated cells device and evaluation of biocompatibility. Frontiers in Neurosciences, May 2021.
- Audouard E, Valentin O, B Meha, N Cartier, C Sevin and Piguet F. Optimized gene therapy approach for metachromatic leukodystrophy by intravenous gene delivery. Frontiers in Biomaterials, June 2021.
- Habbas K., Cakil O., Zambo B., Tabet R., Riet F., Dembele D., Mandel J-L, Hocquemiller M., Laufer R., Piguet F. and Moine H. AAV- delivered diacylglycerol kinase DGKk achieves long-term rescue of fragile X syndrome mouse model. EMBO Mol Med 2022 Apr 4
- Hematopoietic stem cell transplantation chemotherapy causes microglia senescence and peripheral macrophage engraftment in the brain.
- Sailor KA, Agoranos G, López-Manzaneda S, Tada S, Gillet-Legrand B, Guerinot C, Masson JB, Vestergaard CL, Bonner M, Gagnidze K, Veres G, Lledo PM, Cartier N. Nat Med. 2022 Mar;28(3):517-527. doi: 10.1038/s41591-022-01691-9. Epub 2022 Feb 21. PMID: 35190726
Contact
francoise.piguet@icm-institute.org