Presentation
Major publications
- Nóbrega C, Mendonça L, Marcelo A, Lamazière A, Tomé S, Despres G, Matos CA, Mechmet F, Langui D, den Dunnen W, de Almeida LP, Cartier N, Alves S. Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia. Acta Neuropathol. 2019 Nov;138(5):837-858.
- Boussicault L.*, Alves S.*, Lamazière A., Planques A., Heck N., Moumné L., Despres G., Bolte S., -Hue A., Pagès C., Galvan L., Piguet F., Aubourg P., Cartier N.*, Caboche J.* and Betuing S.*. Cyp46-A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington’s Disease. Brain 2016 Mar;139(Pt 3):953-70.
- Fol R., Braudeau J., Ludewig S., Abel T., Weyer S.W., Roederer J.P., Brod F., Audrain M, Bemelmans A.P., Buchholz C.J., Korte M., Cartier N.*#, Müller U.C.*#. Viral gene transfer of APPs rescues synaptic failure in an Alzheimers disease mouse model. Acta Neuropathol. 2015 Nov 4.
- Burlot M.A., Braudeau J., Michaelsen-Preusse K., Potier B., Ayciriex S., Varin J, Gautier B., Djelti F., Audrain M., Dauphinot L., Fernandez-Gomez F.J., Laprévote O., Bièche I., Auzeil N., Potier M.C., Dutar P., Korte M., Buée L., Blum D., Cartier N. Cholesterol24-hydroxylase defect is implicated in memory impairments of Alzheimer-like Tau pathology. Hum Mol Genet. 2015: 24: 5965-76.
- Djelti F., Braudeau J., Hudry E., Dhenain M., Varin J., Bièche I., Marquer C., Chali F., S Ayciriex, Auzeil N., Alves S., Langui D., Potier M.C., Laprevote O., Vidaud M., Duyckaerts C., Miles R., Aubourg P.*, Cartier N.* Cholesterol-24-hydroxylase (CYP46a1) inhibition and accumulation of neuronal cholesterol in hippocampus leads to amyloid production, neurodegeneration and paves the way for Alzheimer’s disease. Brain 2015: 138: 2383-98.
Contact
nathalie.cartier@icm-institute.org