Presentation
The team combines human brain imaging, clinical neuropsychology, monkey neurophysiology and computational modeling:
– To understand how costs and benefits variables are represented in the brain;
– To explain how choice is arbitrated through cognitive control;
– To investigate how the arbitrage is influenced by emotion and fatigue;
– To specify how it varies with clinical conditions and treatments.
Major publications
- Lopez-Persem A, Bastin J, Petton M, Abitbol R, Lehongre K, Adam C, Navarro V, Rheims S, Kahane P, Domenech P, Pessiglione M. Four core properties of the human brain valuation system demonstrated in intracranial signals. Nat Neurosci. 2020 May;23(5):664-675.
- Forgeot d’Arc B, Devaine M, Daunizeau J. Social behavioural adaptation
in Autism. PLoS Comp. Biol. (2020), 16(3): e1007700. - Borderies N, Bornert P., Gilardeau S., Bouret S. Pharmacological evidence for the implication of noradrenaline in effort. PLoS Biol. (2020)
- Blain B, Schmit C, Aubry A, Hausswirth C, Le Meur Y, Pessiglione M. Neuro-computational Impact of Physical Training Overload on Economic Decision-Making. Curr Biol. 2019 Oct 7;29(19):3289-3297.e4.
- Vinckier F, Rigoux L, Oudiette D, Pessiglione M. Neuro-computational
account of how mood fluctuations arise and affect decision making. Nat Commun. 2018 Apr 26;9(1):1708. - Pessiglione M, Vinckier F, Bouret S, Daunizeau J, Le Bouc R. Why not try
harder? Computational approach to motivation deficits in neuro-psychiatric diseases. Brain. 2018 Mar 1;141(3):629-650. - San-Galli A, Varazzani C, Abitbol R, Pessiglione M, Bouret S. Primate Ventromedial Prefrontal Cortex Neurons Continuously Encode the Willingness to Engage in Reward-Directed Behavior. Cereb Cortex. 2018 Jan 1;28(1):73-89.
Contact
mathias.pessiglione@icm-institute.org
jean.daunizeau@icm-institute.org
sebastien.bouret@icm-institute.org
