Neuroimaging core facility
Scientific manager: Stéphane LEHERICY (MD, PhD, PU-PH, Sorbonne university, AP-HP)
Operational manager: Eric BARDINET (Engineer)
CENIR (Center for NeuroImaging Research) is the Institut du Cerveau – ICM main in vivo imaging core facility. With a core set of expertise around neurological diseases, cognitive neuroscience and image analysis, it offers academic and industrial investigators high quality imaging tools for investigating human brain and spinal cord. Personnel with complementary expertise (neurology, neuroimaging, neuroscience, imaging, NMR, image processing, data analysis) design protocols and run the imaging equipment for more than 80 projects each year. The use of 3T MRI, and MRI-compatible EEG creates the perfect environment to conduct neuroimaging projects.
MEG and EEG core facility
Scientific manager: Nathalie GEORGE (PhD, DR2, CNRS)
Operational manager: Laurent HUGUEVILLE (Engineer)
The CENIR-Magnetoencephalography (MEG)/ Electroencephalography (EEG) core facility is part of the Center for NeuroImaging Research (CENIR). The platform aims to develop non-invasive methods that allow visualizing brain activity on a millisecond time scale in normal or pathological conditions. With the latest equipment, the highly skilled team helps academic and industrial partners that wish to undergo clinical or fundamental research to perform the acquisitions as well as to develop integrated analysis tools for multi-level electrophysiological data. CENIR-MEG/ EEG is part of the Institut du Cerveau – ICM core facility network (MRI, PANAM, PRISME…) which facilitates translational research projects.
Physiology and analysis of movement core facility
Scientific manager: Marie-Laure WELTER (MD, PhD, PH, AP-HP)
Operational and scientific manager: Jean-Charles LAMY (PhD)
The PANAM core facility is part of the Center for Neuroimaging Research (CENIR) and focuses on two axis:
1– Clinical research and therapeutics using non-invasive cerebral/spinal stimulations in neurological and psychiatric diseases;
2– The study of movement, gait and balance in patients with neurological diseases. In addition, the facility develops new technics of non-invasive cerebellar stimulation, TMS/MRI, LFP-EEG coupled recordings.
CENIR SA MRI
Small animal MRI core facility
Scientific manager: Alexandra PETIET (Engineer)
Operational manager: Mathieu SANTIN (PhD)
The SA MRI core facility is part of the Center for Neuroimaging Research (CENIR). This platform is dedicated to imaging experimental models of diseases (mainly rodents and potentially any species small enough to fit inside the magnet). A very high magnetic field (11,7 T), associated with high quality probes (Cryoprobe™ for mice), a wide range of imaging protocols and support to data analysis, bring the quality needed for a small animal MRI core facility. CENIR-SA MRI is part of the Institut du Cerveau – ICM core facility network (PHENO-Institut du Cerveau – ICMice, PHENO-PRIMR…) which facilitates translational research projects.
Stéréotaxy core facility
Scientific manager: Carine KARACHI (MD,PhD, MCU-PH, Sorbonne University, AP-HP)
Operational manager: Sara FERNANDEZ VIDAL(Engineer)
STIM is part of the Center for Neuroimaging Research (CENIR) and is dedicated to supporting research done on stereotactic data. It provides specific software development, data analysis, and expertise in neuroimaging processing and electrophysiology. Its main application fields are deep brain stimulation (DBS), surgery (pre, per and post-operatively) and epilepsy. The YeB Atlas, developed by Jérome YELNIK and Eric BARDINET, is a strong support for data analysis. The core facility is involved in several DBS protocols in collaboration with other research institutes and industrials and coordinates the research protocols conducted on epileptic patients of the Pitié-Salpétrière. Interaction with the Pitié-Salpêtrière hospital departments such as neuroradiology, neurosurgery and neurology, adds up to the expertise of the core facility. Stereotactic softwares and models developed by the STIM platform are available to academic partners. CENIR STIM is part of the Institut du Cerveau – ICM core facility network (MRI, MEG/EEG, PANAM, PRISME…) which facilitates translational research projects.
CENIR TEP IRM
Combined PET and MRI core facility
Scientific manager: Marie-Odile HABERT (MD, PhD, PU-PH, Sorbonne University, AP-HP)
Operational manager: Eric BARDINET (Engineer)
A hybrid PET/MR scanner is available in the nuclear medicine department of the hospital La Pitié-Salpêtrière. Combining nuclear imaging with Magnetic Resonance Imaging (MRI) allows acquiring anatomical, functional and molecular images, thus providing a good anatomical reference for a better diagnosis, a shorter time spent in the scanner for the patient as well as a reduced radiation dose. This GE SIGNA integrated PET/MR system allows simultaneous PET and 3T MR imaging without moving the subject in addition to being able to measure the time of flight of the PET emission data. The combination of PET and MR imaging raises new methodological challenges, like photon attenuation correction, but also offers new opportunities such as motion correction, MR-guided PET image reconstruction and multi-parametric imaging.
Human behavior exploration core facility
Scientific manager: Mathias PESSIGLIONE (PhD, DR2, INSERM)
Operational manager: Karim N’DIAYE (PhD)
PRISME is the Institut du Cerveau – ICM’s core facility dedicated to the functional exploration of human behavior. It is divided into 2 entities:
1–PRISME-Virtual Reality that focuses on developing and adapting new paradigms of virtual reality for behavioral and cognitive neuroscience. The facility also means to set up new therapeutic protocols applied to neuropsychiatric diseases;
2–PRISME-Real life that is dedicated to the study of human cognitive functions, motor performance and social interaction in an ecological environment. Academic and industrial partners have access to the equipment and are helped by the team to design needed protocols.